2xpy: Difference between revisions
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==Structure of Native Leukotriene A4 Hydrolase from Saccharomyces cerevisiae== | ==Structure of Native Leukotriene A4 Hydrolase from Saccharomyces cerevisiae== | ||
<StructureSection load='2xpy' size='340' side='right' caption='[[2xpy]], [[Resolution|resolution]] 2.73Å' scene=''> | <StructureSection load='2xpy' size='340' side='right'caption='[[2xpy]], [[Resolution|resolution]] 2.73Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xpy]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2xpy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XPY FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.73Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr><td class="sblockLbl"><b> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpy OCA], [https://pdbe.org/2xpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xpy RCSB], [https://www.ebi.ac.uk/pdbsum/2xpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xpy ProSAT]</span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </table> | ||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/LKHA4_YEAST LKHA4_YEAST] Aminopeptidase that preferentially cleaves tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze an epoxide moiety of LTA(4) to form LTB(4) (in vitro).<ref>PMID:10574934</ref> <ref>PMID:11601994</ref> <ref>PMID:16024909</ref> <ref>PMID:16597475</ref> <ref>PMID:21146536</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit upon Inhibitor Binding.,Helgstrand C, Hasan M, Uysal H, Haeggstrom JZ, Thunnissen MM J Mol Biol. 2010 Dec 10. PMID:21146536<ref>PMID:21146536</ref> | A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit upon Inhibitor Binding.,Helgstrand C, Hasan M, Uysal H, Haeggstrom JZ, Thunnissen MM J Mol Biol. 2010 Dec 10. PMID:21146536<ref>PMID:21146536</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2xpy" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Leukotriene A4 Hydrolase|Leukotriene A4 Hydrolase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Haeggstrom | [[Category: Haeggstrom JZ]] | ||
[[Category: Hasan | [[Category: Hasan M]] | ||
[[Category: Helgstrand | [[Category: Helgstrand C]] | ||
[[Category: Thunnissen | [[Category: Thunnissen MMGM]] | ||
[[Category: Usyal | [[Category: Usyal H]] | ||