2mju: Difference between revisions
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==Solution structure of a C terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)== | ==Solution structure of a C terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)== | ||
<StructureSection load='2mju' size='340' side='right' caption='[[2mju | <StructureSection load='2mju' size='340' side='right'caption='[[2mju]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mju]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2mju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJU FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr><td class="sblockLbl"><b> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mju OCA], [https://pdbe.org/2mju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mju RCSB], [https://www.ebi.ac.uk/pdbsum/2mju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mju ProSAT]</span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </table> | ||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/PTBP2_HUMAN PTBP2_HUMAN] RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.<ref>PMID:11003644</ref> <ref>PMID:12667457</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB).,Joshi A, Esteve V, Buckroyd AN, Blatter M, Allain FH, Curry S PeerJ. 2014 Mar 13;2:e305. doi: 10.7717/peerj.305. eCollection 2014. PMID:24688880<ref>PMID:24688880</ref> | Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB).,Joshi A, Esteve V, Buckroyd AN, Blatter M, Allain FH, Curry S PeerJ. 2014 Mar 13;2:e305. doi: 10.7717/peerj.305. eCollection 2014. PMID:24688880<ref>PMID:24688880</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2mju" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Allain FH-T]] | ||
[[Category: | [[Category: Blatter M]] | ||
[[Category: | [[Category: Esteve V]] | ||