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==Crystal Structure of Ribonuclease A Variant A4C/D83E/V118C==
==Crystal Structure of Ribonuclease A Variant A4C/D83E/V118C==
<StructureSection load='3ql2' size='340' side='right' caption='[[3ql2]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
<StructureSection load='3ql2' size='340' side='right'caption='[[3ql2]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ql2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QL2 OCA]. <br>
<table><tr><td colspan='2'>[[3ql2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QL2 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ql1|3ql1]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RNASE1, RNS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ql2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ql2 OCA], [https://pdbe.org/3ql2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ql2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ql2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ql2 ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ql2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ql2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ql2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ql2 PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Significant stabilization of ribonuclease A by additive effects.,Arnold U, Schopfel M FEBS J. 2012 May 17. doi: 10.1111/j.1742-4658.2012.08632.x. PMID:22594773<ref>PMID:22594773</ref>
Significant stabilization of ribonuclease A by additive effects.,Arnold U, Schopfel M FEBS J. 2012 May 17. doi: 10.1111/j.1742-4658.2012.08632.x. PMID:22594773<ref>PMID:22594773</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3ql2" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bovin]]
[[Category: Bos taurus]]
[[Category: Pancreatic ribonuclease]]
[[Category: Large Structures]]
[[Category: Arnold, U.]]
[[Category: Arnold U]]
[[Category: Schoepfel, M.]]
[[Category: Schoepfel M]]
[[Category: Disulfide bond]]
[[Category: Folding]]
[[Category: Hydrolase]]
[[Category: Proteolysis]]
[[Category: Ribonuclease some]]
[[Category: Salt bridge]]
[[Category: Site-directed mutagenesis]]
[[Category: Stability]]

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