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{{STRUCTURE_1jth|  PDB=1jth  |  SCENE=  }}
===Crystal structure and biophysical properties of a complex between the N-terminal region of SNAP25 and the SNARE region of syntaxin 1a===
{{ABSTRACT_PUBMED_11533035}}


==Function==
==Crystal structure and biophysical properties of a complex between the N-terminal region of SNAP25 and the SNARE region of syntaxin 1a==
[[http://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.  
<StructureSection load='1jth' size='340' side='right'caption='[[1jth]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1jth]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JTH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jth OCA], [https://pdbe.org/1jth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jth RCSB], [https://www.ebi.ac.uk/pdbsum/1jth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jth ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/1jth_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jth ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
[[1jth]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTH OCA].
*[[Synaptosomal-associated protein|Synaptosomal-associated protein]]
 
*[[Syntaxin 3D structures|Syntaxin 3D structures]]
==Reference==
__TOC__
<ref group="xtra">PMID:011533035</ref><references group="xtra"/><references/>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Gonzalez, L C.]]
[[Category: Rattus norvegicus]]
[[Category: May, A P.]]
[[Category: Gonzalez Jr LC]]
[[Category: Misura, K M.S.]]
[[Category: May AP]]
[[Category: Scheller, R H.]]
[[Category: Misura KMS]]
[[Category: Weis, W I.]]
[[Category: Scheller RH]]
[[Category: Coiled-coil]]
[[Category: Weis WI]]
[[Category: Endocytosis-exocytosis complex]]
[[Category: Polar layer]]

Latest revision as of 16:25, 13 March 2024

Crystal structure and biophysical properties of a complex between the N-terminal region of SNAP25 and the SNARE region of syntaxin 1aCrystal structure and biophysical properties of a complex between the N-terminal region of SNAP25 and the SNARE region of syntaxin 1a

Structural highlights

1jth is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SNP25_RAT t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1jth, resolution 2.00Å

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