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== | ==Crystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and Homocysteine== | ||
[[http://www.uniprot.org/uniprot/METE_CANAL METE_CANAL | <StructureSection load='4l6h' size='340' side='right'caption='[[4l6h]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4l6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L6H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HCS:2-AMINO-4-MERCAPTO-BUTYRIC+ACID'>HCS</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l6h OCA], [https://pdbe.org/4l6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l6h RCSB], [https://www.ebi.ac.uk/pdbsum/4l6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l6h ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/METE_CANAL METE_CANAL] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172] | |||
== | ==See Also== | ||
[[ | *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Candida albicans SC5314]] | |||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Robertus JD]] | ||
[[Category: | [[Category: Ubhi D]] | ||
[[Category: | |||
Latest revision as of 15:17, 1 March 2024
Crystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and HomocysteineCrystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and Homocysteine
Structural highlights
FunctionMETE_CANAL Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172] See Also |
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