4led: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{STRUCTURE_4led|  PDB=4led  |  SCENE=  }}
-===The Crystal Structure of Pyocin L1 bound to D-rhamnose at 2.37 Angstroms===
-{{ABSTRACT_PUBMED_24516380}}
-==About this Structure==
+==The Crystal Structure of Pyocin L1 bound to D-rhamnose at 2.37 Angstroms==
-[[4led]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LED OCA].
+<StructureSection load='4led' size='340' side='right'caption='[[4led]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4led]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_str._C_1433 Pseudomonas aeruginosa str. C 1433]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LED FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XXR:6-DEOXY-ALPHA-D-MANNOPYRANOSE'>XXR</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4led OCA], [https://pdbe.org/4led PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4led RCSB], [https://www.ebi.ac.uk/pdbsum/4led PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4led ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/T2LG16_PSEAI T2LG16_PSEAI]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel member of this family from Pseudomonas aeruginosa, targets susceptible strains of this species through recognition of the common polysaccharide antigen (CPA) of P. aeruginosa lipopolysaccharide that is predominantly a homopolymer of d-rhamnose. Structural and biophysical analyses show that recognition of CPA occurs through the C-terminal carbohydrate-binding domain of pyocin L1 and that this interaction is a prerequisite for bactericidal activity. Further to this, we show that the previously described lectin-like bacteriocin putidacin L1 shows a similar carbohydrate-binding specificity, indicating that oligosaccharides containing d-rhamnose and not d-mannose, as was previously thought, are the physiologically relevant ligands for this group of bacteriocins. The widespread inclusion of d-rhamnose in the lipopolysaccharide of members of the genus Pseudomonas explains the unusual genus-specific activity of the lectin-like bacteriocins.
-==Reference==
+Lectin-Like Bacteriocins from Pseudomonas spp. Utilise D-Rhamnose Containing Lipopolysaccharide as a Cellular Receptor.,McCaughey LC, Grinter R, Josts I, Roszak AW, Waloen KI, Cogdell RJ, Milner J, Evans T, Kelly S, Tucker NP, Byron O, Smith B, Walker D PLoS Pathog. 2014 Feb 6;10(2):e1003898. doi: 10.1371/journal.ppat.1003898., eCollection 2014 Feb. PMID:24516380<ref>PMID:24516380</ref>
-<ref group="xtra">PMID:024516380</ref><references group="xtra"/><references/>
-[[Category: Cogdell, C J.]]
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Grinter, R.]]
+</div>
-[[Category: Mccaughey, L.]]
+<div class="pdbe-citations 4led" style="background-color:#fffaf0;"></div>
-[[Category: Roszak, A W.]]
+== References ==
-[[Category: Walker, D.]]
+<references/>
-[[Category: Antimicrobial protein]]
+__TOC__
-[[Category: Bacteriocin]]
+</StructureSection>
-[[Category: Beta prism]]
+[[Category: Large Structures]]
-[[Category: Extracellular]]
+[[Category: Pseudomonas aeruginosa str. C 1433]]
-[[Category: Galanthus nivalis agglutinin]]
+[[Category: Cogdell CJ]]
-[[Category: Monocot mannose binding protein]]
+[[Category: Grinter R]]
-[[Category: Sugar binding protein]]
+[[Category: Mccaughey L]]
+[[Category: Roszak AW]]
+[[Category: Walker D]]