4jgv: Difference between revisions

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{{STRUCTURE_4jgv|  PDB=4jgv  |  SCENE=  }}
===Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN===
{{ABSTRACT_PUBMED_24316735}}


==Function==
==Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN==
[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
<StructureSection load='4jgv' size='340' side='right'caption='[[4jgv]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4jgv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGV FirstGlance]. <br>
[[4jgv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGV OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=T94:1-(3,4,5-TRIHYDROXYPHENYL)NONAN-1-ONE'>T94</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgv OCA], [https://pdbe.org/4jgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgv RCSB], [https://www.ebi.ac.uk/pdbsum/4jgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgv ProSAT]</span></td></tr>
<ref group="xtra">PMID:024316735</ref><references group="xtra"/><references/>
</table>
[[Category: Chen, H.]]
== Function ==
[[Category: Li, A.]]
[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>  
[[Category: Li, F.]]
== References ==
[[Category: Lin, T.]]
<references/>
[[Category: Tian, X.]]
__TOC__
[[Category: Wan, W.]]
</StructureSection>
[[Category: Wan, Y.]]
[[Category: Homo sapiens]]
[[Category: Wu, Q.]]
[[Category: Large Structures]]
[[Category: Xing, Y.]]
[[Category: Chen H]]
[[Category: Zhang, Q.]]
[[Category: Li A]]
[[Category: Transcription]]
[[Category: Li F]]
[[Category: Lin T]]
[[Category: Tian X]]
[[Category: Wan W]]
[[Category: Wan Y]]
[[Category: Wu Q]]
[[Category: Xing Y]]
[[Category: Zhang Q]]

Latest revision as of 11:53, 20 March 2024

Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPNCrystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN

Structural highlights

4jgv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.01Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NR4A1_HUMAN Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.[1]

References

  1. ↑ Harant H, Lindley IJ. Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. Nucleic Acids Res. 2004 Oct 5;32(17):5280-90. Print 2004. PMID:15466594 doi:10.1093/nar/gkh856

4jgv, resolution 3.01Å

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OCA
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