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{{STRUCTURE_4ldv|  PDB=4ldv  |  SCENE=  }}
===Crystal structure of the DNA binding domain of A. thailana auxin response factor 1===
{{ABSTRACT_PUBMED_24485461}}


==Function==
==Crystal structure of the DNA binding domain of A. thailana auxin response factor 1==
[[http://www.uniprot.org/uniprot/ARFA_ARATH ARFA_ARATH]] Auxin response factors (ARFs) are transcriptional factors that binds specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Promotes flowering, stamen development, floral organ abscission and fruit dehiscence. Acts as repressor of IAA2, IAA3 and IAA7.<ref>PMID:12036261</ref> <ref>PMID:16176952</ref>
<StructureSection load='4ldv' size='340' side='right'caption='[[4ldv]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4ldv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDV FirstGlance]. <br>
[[4ldv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDV OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldv OCA], [https://pdbe.org/4ldv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldv RCSB], [https://www.ebi.ac.uk/pdbsum/4ldv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldv ProSAT]</span></td></tr>
<ref group="xtra">PMID:024485461</ref><references group="xtra"/><references/>
</table>
[[Category: Berg, W M.A van den.]]
== Function ==
[[Category: Coll, M.]]
[https://www.uniprot.org/uniprot/ARFA_ARATH ARFA_ARATH] Auxin response factors (ARFs) are transcriptional factors that binds specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Promotes flowering, stamen development, floral organ abscission and fruit dehiscence. Acts as repressor of IAA2, IAA3 and IAA7.<ref>PMID:12036261</ref> <ref>PMID:16176952</ref>  
[[Category: Freire-Rios, A.]]
== References ==
[[Category: Weijers, D.]]
<references/>
[[Category: Boer, D R.]]
__TOC__
[[Category: Dna binding]]
</StructureSection>
[[Category: Nucleus]]
[[Category: Arabidopsis thaliana]]
[[Category: Transcription]]
[[Category: Large Structures]]
[[Category: Transcription factor]]
[[Category: Coll M]]
[[Category: Freire-Rios A]]
[[Category: Weijers D]]
[[Category: Boer DR]]
[[Category: Van den Berg WMA]]

Latest revision as of 15:19, 1 March 2024

Crystal structure of the DNA binding domain of A. thailana auxin response factor 1Crystal structure of the DNA binding domain of A. thailana auxin response factor 1

Structural highlights

4ldv is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.45Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ARFA_ARATH Auxin response factors (ARFs) are transcriptional factors that binds specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Promotes flowering, stamen development, floral organ abscission and fruit dehiscence. Acts as repressor of IAA2, IAA3 and IAA7.[1] [2]

References

  1. ↑ Hagen G, Guilfoyle T. Auxin-responsive gene expression: genes, promoters and regulatory factors. Plant Mol Biol. 2002 Jun-Jul;49(3-4):373-85. PMID:12036261
  2. ↑ Ellis CM, Nagpal P, Young JC, Hagen G, Guilfoyle TJ, Reed JW. AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana. Development. 2005 Oct;132(20):4563-74. Epub 2005 Sep 21. PMID:16176952 doi:http://dx.doi.org/dev.02012

4ldv, resolution 1.45Å

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