3lkx: Difference between revisions

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-{{STRUCTURE_3lkx|  PDB=3lkx  |  SCENE=  }}
-===Human nac dimerization domain===
-{{ABSTRACT_PUBMED_20214399}}
-==Function==
+==Human nac dimerization domain==
-[[http://www.uniprot.org/uniprot/BTF3_HUMAN BTF3_HUMAN]] General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription. [[http://www.uniprot.org/uniprot/NACA_HUMAN NACA_HUMAN]] Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.<ref>PMID:9877153</ref> <ref>PMID:10982809</ref> <ref>PMID:15784678</ref>
+<StructureSection load='3lkx' size='340' side='right'caption='[[3lkx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3lkx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LKX FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lkx OCA], [https://pdbe.org/3lkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lkx RCSB], [https://www.ebi.ac.uk/pdbsum/3lkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lkx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BTF3_HUMAN BTF3_HUMAN] General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lk/3lkx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lkx ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In archaea and eukaryotes, the nascent polypeptide-associated complex (NAC) is one of the cytosolic chaperones that contact the nascent polypeptide chains as they emerge from the ribosome and assist in post-translational processes. The eukaryotic NAC is a heterodimer, and its two subunits form a stable complex through a dimerizing domain called the NAC domain. In addition to acting as a protein translation chaperone, the NAC subunits also function individually in transcriptional regulation. Here we report the crystal structure of the human NAC domain, which reveals the manner of human NAC dimerization. On the basis of the structure, we identified a region in the NAC domain of the human NAC alpha-subunit as a new nucleic acid-binding region, which is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit.
-==About this Structure==
+The Crystal Structure of the Human Nascent Polypeptide-Associated Complex Domain Reveals a Nucleic Acid-Binding Region on the NACA Subunit .,Liu Y, Hu Y, Li X, Niu L, Teng M Biochemistry. 2010 Mar 16. PMID:20214399<ref>PMID:20214399</ref>
-[[3lkx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LKX OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:020214399</ref><references group="xtra"/><references/>
+</div>
-[[Category: Human]]
+<div class="pdbe-citations 3lkx" style="background-color:#fffaf0;"></div>
-[[Category: Hu, Y.]]
-[[Category: Li, X.]]
+==See Also==
-[[Category: Liu, Y.]]
+*[[NAC transcription factor|NAC transcription factor]]
-[[Category: Niu, L.]]
+== References ==
-[[Category: Teng, M.]]
+<references/>
-[[Category: Beta-barrel]]
+__TOC__
-[[Category: Chaperone]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Hu Y]]
+[[Category: Li X]]
+[[Category: Liu Y]]
+[[Category: Niu L]]
+[[Category: Teng M]]