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===ICD structure===
===ICD structure===


A distinctive feature of the MDR-ABC transporter family is two extensive intracellular regions called <scene name='56/568010/Icd1/3'>ICD1</scene> (residues 97 to 139) <scene name='56/568010/Icd2/3'>ICD2</scene> (residues 193 to 252) and <scene name='56/568010/Icd3/2'>ICD3</scene> (residues 302 to 327).
A distinctive feature of the MDR-ABC transporter family is two extensive intracellular regions called <scene name='56/568010/Icd1/3'>ICD1</scene> (residues 97 to 139) <scene name='56/568010/Icd2/3'>ICD2</scene> (residues 193 to 252) and <scene name='56/568010/Icd3/2'>ICD3</scene> (residues 302 to 327). ICD1, which is sandwiched between ICD2 and the NBD, is composed of three α-helices connected by short loops to form a "U"-like structure. ICD3 links TM6 and the NBD and forms two α-helices connected by short loops.
<scene name='56/568010/Icd1/3'>ICD1</scene>, which is sandwiched between ICD2 and the NBD, is composed of three α-helices connected by short loops to form a "U"-like structure. ICD3 links TM6 and the NBD and forms two α-helices connected by short loops.


===Chamber structure===
===Chamber structure===

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OCA, Hélène Vignes, Daniel Thédié