4nnw: Difference between revisions
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The | ==yCP in complex with Z-Leu-Leu-Leu-ketoaldehyde== | ||
<StructureSection load='4nnw' size='340' side='right'caption='[[4nnw]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4nnw]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NNW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MK:N-[(BENZYLOXY)CARBONYL]-L-LEUCYL-N-[(2R,3S)-1,2-DIHYDROXY-5-METHYLHEXAN-3-YL]-L-LEUCINAMIDE'>2MK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nnw OCA], [https://pdbe.org/4nnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nnw RCSB], [https://www.ebi.ac.uk/pdbsum/4nnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nnw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | |||
==See Also== | |||
*[[Proteasome 3D structures|Proteasome 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Beck P]] | |||
[[Category: Cui H]] | |||
[[Category: Dubiella C]] | |||
[[Category: Groll M]] | |||
[[Category: Krueger A]] | |||
[[Category: Schmidt B]] | |||
[[Category: Stein ML]] | |||
[[Category: Voss C]] | |||
Latest revision as of 17:07, 13 March 2024
yCP in complex with Z-Leu-Leu-Leu-ketoaldehydeyCP in complex with Z-Leu-Leu-Leu-ketoaldehyde
Structural highlights
FunctionPSA2_YEAST The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. See Also |
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