4l75: Difference between revisions

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-{{STRUCTURE_4l75|  PDB=4l75  |  SCENE=  }}
-===Ca2+-bound D184N mutant MthK RCK domain at 2.4 Angstrom===
-{{ABSTRACT_PUBMED_24126388}}
-==Function==
+==Ca2+-bound D184N mutant MthK RCK domain at 2.4 Angstrom==
-[[http://www.uniprot.org/uniprot/MTHK_METTH MTHK_METTH]] Calcium-gated potassium channel.
+<StructureSection load='4l75' size='340' side='right'caption='[[4l75]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4l75]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L75 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.393&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l75 OCA], [https://pdbe.org/4l75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l75 RCSB], [https://www.ebi.ac.uk/pdbsum/4l75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l75 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MTHK_METTH MTHK_METTH] Calcium-gated potassium channel.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Ligand binding sites within proteins can interact by allosteric mechanisms to modulate binding affinities and control protein function. Here we present crystal structures of the regulator of K(+) conductance (RCK) domain from a K(+) channel, MthK, which reveal the structural basis of allosteric coupling between two Ca(2+) regulatory sites within the domain. Comparison of RCK domain crystal structures in a range of conformations and with different numbers of regulatory Ca(2+) ions bound, combined with complementary electrophysiological analysis of channel gating, suggests chemical interactions that are important for modulation of ligand binding and subsequent channel opening.
-==About this Structure==
+Structural basis of allosteric interactions among Ca(2+)-binding sites in a K(+) channel RCK domain.,Smith FJ, Pau VP, Cingolani G, Rothberg BS Nat Commun. 2013;4:2621. doi: 10.1038/ncomms3621. PMID:24126388<ref>PMID:24126388</ref>
-[[4l75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Metth Metth]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L75 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:024126388</ref><references group="xtra"/><references/>
+</div>
-[[Category: Metth]]
+<div class="pdbe-citations 4l75" style="background-color:#fffaf0;"></div>
-[[Category: Rothberg, B S.]]
-[[Category: Smith, F J.]]
+==See Also==
-[[Category: Calcium binding]]
+*[[Potassium channel 3D structures|Potassium channel 3D structures]]
-[[Category: Membrane-associated]]
+== References ==
-[[Category: Metal transport]]
+<references/>
-[[Category: Regulatory domain]]
+__TOC__
-[[Category: Rossmann fold]]
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Methanothermobacter thermautotrophicus str. Delta H]]
+[[Category: Rothberg BS]]
+[[Category: Smith FJ]]