3qi3: Difference between revisions

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-{{STRUCTURE_3qi3|  PDB=3qi3  |  SCENE=  }}
-===Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691===
-{{ABSTRACT_PUBMED_21483814}}
-==Function==
+==Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691==
-[[http://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN]] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
+<StructureSection load='3qi3' size='340' side='right'caption='[[3qi3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[3qi3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QI3 FirstGlance]. <br>
-[[3qi3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI3 OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDB:1-(2-CHLOROPHENYL)-6-[(2R)-3,3,3-TRIFLUORO-2-METHYLPROPYL]-1,7-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE'>PDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qi3 OCA], [https://pdbe.org/3qi3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qi3 RCSB], [https://www.ebi.ac.uk/pdbsum/3qi3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qi3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
 ==See Also==
-*[[Phosphodiesterase|Phosphodiesterase]]
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:021483814</ref><references group="xtra"/><references/>
+__TOC__
-[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
+</StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Hou, J.]]
+[[Category: Large Structures]]
-[[Category: Ke, H.]]
+[[Category: Hou J]]
-[[Category: Liu, M.]]
+[[Category: Ke H]]
-[[Category: Lou, H.]]
+[[Category: Liu M]]
-[[Category: Xu, J.]]
+[[Category: Lou H]]
-[[Category: Zhao, R.]]
+[[Category: Xu J]]
-[[Category: Glutamine switch]]
+[[Category: Zhao R]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]
-[[Category: Mutation]]