2pq5: Difference between revisions

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-[[Image:2pq5.gif|left|200px]]<br /><applet load="2pq5" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2pq5, resolution 2.30&Aring;" />
-'''Crystal structure of Dual specificity protein phosphatase 13 (DUSP13)'''<br />
-==About this Structure==
+==Crystal structure of Dual specificity protein phosphatase 13 (DUSP13)==
-PQ5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PQ5 OCA].
+<StructureSection load='2pq5' size='340' side='right'caption='[[2pq5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2pq5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PQ5 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pq5 OCA], [https://pdbe.org/2pq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pq5 RCSB], [https://www.ebi.ac.uk/pdbsum/2pq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pq5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DS13B_HUMAN DS13B_HUMAN] Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.<ref>PMID:21360282</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pq/2pq5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pq5 ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith CH]]
-[[Category: Barr, A.]]
+[[Category: Barr A]]
-[[Category: Berridge, G.]]
+[[Category: Berridge G]]
-[[Category: Bunkoczi, G.]]
+[[Category: Bunkoczi G]]
-[[Category: Burgess-Brown, N.]]
+[[Category: Burgess-Brown N]]
-[[Category: Delft, A von.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Knapp S]]
-[[Category: Knapp, S.]]
+[[Category: Niesen F]]
-[[Category: Niesen, F.]]
+[[Category: Pantic N]]
-[[Category: Pantic, N.]]
+[[Category: Pike ACW]]
-[[Category: Pike, A C.W.]]
+[[Category: Salah E]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Savitsky P]]
-[[Category: Salah, E.]]
+[[Category: Sundstrom M]]
-[[Category: Savitsky, P.]]
+[[Category: Ugochukwu E]]
-[[Category: Sundstrom, M.]]
+[[Category: Uppenberg J]]
-[[Category: Ugochukwu, E.]]
+[[Category: Weigelt J]]
-[[Category: Uppenberg, J.]]
+[[Category: Von Delft F]]
-[[Category: Weigelt, J.]]
-[[Category: dual specificity phosphatase]]
-[[Category: dusp13]]
-[[Category: hydrolase]]
-[[Category: protein phosphatase]]
-[[Category: sgc]]
-[[Category: structural genomics]]
-[[Category: structural genomics consortium]]
-[[Category: testis and skeletal muscle specific dsp]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:31:57 2008''