4mvt: Difference between revisions

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-'''Unreleased structure'''
-The entry 4mvt is ON HOLD
+==Crystal structure of SUMO E3 Ligase PIAS3==
+<StructureSection load='4mvt' size='340' side='right'caption='[[4mvt]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Dong, A., Hu, J., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4mvt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MVT FirstGlance]. <br>
-Description: Crystal structure of SUMO E3 Ligase PIAS3
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvt OCA], [https://pdbe.org/4mvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mvt RCSB], [https://www.ebi.ac.uk/pdbsum/4mvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mvt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PIAS3_HUMAN PIAS3_HUMAN] Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.<ref>PMID:9388184</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Arrowsmith CH]]
+[[Category: Bountra C]]
+[[Category: Dong A]]
+[[Category: Edwards AM]]
+[[Category: Hu J]]
+[[Category: Li Y]]
+[[Category: Tempel W]]
+[[Category: Tong Y]]