2ojv: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2ojv.gif|left|200px]]<br /><applet load="2ojv" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2ojv, resolution 2.40&Aring;" />
-'''Crystal structure of a ternary complex of goat lactoperoxidase with cyanide and iodide ions at 2.4 A resolution'''<br />
-==About this Structure==
+==Crystal structure of a ternary complex of goat lactoperoxidase with cyanide and iodide ions at 2.4 A resolution==
-OJV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CYN:'>CYN</scene>, <scene name='pdbligand=CO3:'>CO3</scene>, <scene name='pdbligand=IOD:'>IOD</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJV OCA].
+<StructureSection load='2ojv' size='340' side='right'caption='[[2ojv]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ojv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OJV FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ojv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ojv OCA], [https://pdbe.org/2ojv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ojv RCSB], [https://www.ebi.ac.uk/pdbsum/2ojv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ojv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PERL_CAPHI PERL_CAPHI] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).<ref>PMID:10894086</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oj/2ojv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ojv ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Lactoperoxidase|Lactoperoxidase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Capra hircus]]
-[[Category: Peroxidase]]
+[[Category: Large Structures]]
-[[Category: Protein complex]]
+[[Category: Kaur P]]
-[[Category: Kaur, P.]]
+[[Category: Sharma S]]
-[[Category: Sharma, S.]]
+[[Category: Singh AK]]
-[[Category: Singh, A K.]]
+[[Category: Singh N]]
-[[Category: Singh, N.]]
+[[Category: Singh SB]]
-[[Category: Singh, S B.]]
+[[Category: Singh TP]]
-[[Category: Singh, T P.]]
-[[Category: CA]]
-[[Category: CO3]]
-[[Category: CYN]]
-[[Category: HEM]]
-[[Category: IOD]]
-[[Category: complex]]
-[[Category: cyanide]]
-[[Category: heam]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:19:18 2008''