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{{STRUCTURE_4l4t|  PDB=4l4t  |  SCENE=  }}
===Structure of human MAIT TCR in complex with human MR1-6-FP===
{{ABSTRACT_PUBMED_23846752}}


==Disease==
==Structure of human MAIT TCR in complex with human MR1-6-FP==
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
<StructureSection load='4l4t' size='340' side='right'caption='[[4l4t]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4l4t]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L4T FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6FP:2-AMINO-4-OXO-3,4-DIHYDROPTERIDINE-6-CARBALDEHYDE'>6FP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4t OCA], [https://pdbe.org/4l4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l4t RCSB], [https://www.ebi.ac.uk/pdbsum/4l4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l4t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The mucosal-associated invariant T-cell antigen receptor (MAIT TCR) recognizes MR1 presenting vitamin B metabolites. Here we describe the structures of a human MAIT TCR in complex with human MR1 presenting a non-stimulatory ligand derived from folic acid and an agonist ligand derived from a riboflavin metabolite. For both vitamin B antigens, the MAIT TCR docks in a conserved manner above MR1, thus acting as an innate-like pattern recognition receptor. The invariant MAIT TCR alpha-chain usage is attributable to MR1-mediated interactions that prise open the MR1 cleft to allow contact with the vitamin B metabolite. Although the non-stimulatory antigen does not contact the MAIT TCR, the stimulatory antigen does. This results in a higher affinity of the MAIT TCR for a stimulatory antigen in comparison with a non-stimulatory antigen. We formally demonstrate a structural basis for MAIT TCR recognition of vitamin B metabolites, while illuminating how TCRs recognize microbial metabolic signatures.


==Function==
Recognition of vitamin B metabolites by mucosal-associated invariant T cells.,Patel O, Kjer-Nielsen L, Le Nours J, Eckle SB, Birkinshaw R, Beddoe T, Corbett AJ, Liu L, Miles JJ, Meehan B, Reantragoon R, Sandoval-Romero ML, Sullivan LC, Brooks AG, Chen Z, Fairlie DP, McCluskey J, Rossjohn J Nat Commun. 2013;4:2142. doi: 10.1038/ncomms3142. PMID:23846752<ref>PMID:23846752</ref>
[[http://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN]] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[4l4t]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4T OCA].
</div>
<div class="pdbe-citations 4l4t" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
 
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:023846752</ref><references group="xtra"/><references/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Beddoe, T.]]
[[Category: Large Structures]]
[[Category: Birkinshaw, R W.]]
[[Category: Beddoe T]]
[[Category: Brooks, A G.]]
[[Category: Birkinshaw RW]]
[[Category: Chen, Z.]]
[[Category: Brooks AG]]
[[Category: Corbett, A J.]]
[[Category: Chen Z]]
[[Category: Eckle, S B.G.]]
[[Category: Corbett AJ]]
[[Category: Fairlie, D P.]]
[[Category: Eckle SBG]]
[[Category: Kjer-Nielsen, L.]]
[[Category: Fairlie DP]]
[[Category: Liu, L.]]
[[Category: Kjer-Nielsen L]]
[[Category: McCluskey, J.]]
[[Category: Le Nours J]]
[[Category: Meehan, B.]]
[[Category: Liu L]]
[[Category: Miles, J J.]]
[[Category: McCluskey J]]
[[Category: Nours, J Le.]]
[[Category: Meehan B]]
[[Category: Patel, O.]]
[[Category: Miles JJ]]
[[Category: Reantragoon, R.]]
[[Category: Patel O]]
[[Category: Rossjohn, J.]]
[[Category: Reantragoon R]]
[[Category: Sandoval-Romero, M L.]]
[[Category: Rossjohn J]]
[[Category: Sullivan, L C.]]
[[Category: Sandoval-Romero ML]]
[[Category: Immune system]]
[[Category: Sullivan LC]]
[[Category: Mait tcr]]
[[Category: Membrane protein-immune system complex]]
[[Category: Mhc class i-related protein]]
[[Category: Vitamin b metabolite]]

Latest revision as of 19:11, 20 September 2023

Structure of human MAIT TCR in complex with human MR1-6-FPStructure of human MAIT TCR in complex with human MR1-6-FP

Structural highlights

4l4t is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HMR1_HUMAN Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.[1]

Publication Abstract from PubMed

The mucosal-associated invariant T-cell antigen receptor (MAIT TCR) recognizes MR1 presenting vitamin B metabolites. Here we describe the structures of a human MAIT TCR in complex with human MR1 presenting a non-stimulatory ligand derived from folic acid and an agonist ligand derived from a riboflavin metabolite. For both vitamin B antigens, the MAIT TCR docks in a conserved manner above MR1, thus acting as an innate-like pattern recognition receptor. The invariant MAIT TCR alpha-chain usage is attributable to MR1-mediated interactions that prise open the MR1 cleft to allow contact with the vitamin B metabolite. Although the non-stimulatory antigen does not contact the MAIT TCR, the stimulatory antigen does. This results in a higher affinity of the MAIT TCR for a stimulatory antigen in comparison with a non-stimulatory antigen. We formally demonstrate a structural basis for MAIT TCR recognition of vitamin B metabolites, while illuminating how TCRs recognize microbial metabolic signatures.

Recognition of vitamin B metabolites by mucosal-associated invariant T cells.,Patel O, Kjer-Nielsen L, Le Nours J, Eckle SB, Birkinshaw R, Beddoe T, Corbett AJ, Liu L, Miles JJ, Meehan B, Reantragoon R, Sandoval-Romero ML, Sullivan LC, Brooks AG, Chen Z, Fairlie DP, McCluskey J, Rossjohn J Nat Commun. 2013;4:2142. doi: 10.1038/ncomms3142. PMID:23846752[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Miley MJ, Truscott SM, Yu YY, Gilfillan S, Fremont DH, Hansen TH, Lybarger L. Biochemical features of the MHC-related protein 1 consistent with an immunological function. J Immunol. 2003 Jun 15;170(12):6090-8. PMID:12794138
  2. ↑ Patel O, Kjer-Nielsen L, Le Nours J, Eckle SB, Birkinshaw R, Beddoe T, Corbett AJ, Liu L, Miles JJ, Meehan B, Reantragoon R, Sandoval-Romero ML, Sullivan LC, Brooks AG, Chen Z, Fairlie DP, McCluskey J, Rossjohn J. Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nat Commun. 2013;4:2142. doi: 10.1038/ncomms3142. PMID:23846752 doi:10.1038/ncomms3142

4l4t, resolution 2.00Å

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