4m6q: Difference between revisions
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New page: '''Unreleased structure''' The entry 4m6q is ON HOLD Authors: Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao,... |
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==Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)== | |||
<StructureSection load='4m6q' size='340' side='right'caption='[[4m6q]], [[Resolution|resolution]] 2.41Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4m6q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M6Q FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.406Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=20T:1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-N-(4-{[3-(TRIFLUOROMETHYL)PHENYL]SULFONYL}BENZYL)-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE'>20T</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6q OCA], [https://pdbe.org/4m6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m6q RCSB], [https://www.ebi.ac.uk/pdbsum/4m6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6q ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | |||
==See Also== | |||
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bravo B]] | |||
[[Category: Dragovich PS]] | |||
[[Category: Feng Y]] | |||
[[Category: Giannetti AM]] | |||
[[Category: Gunzner-Toste J]] | |||
[[Category: Ho Y]] | |||
[[Category: Hua R]] | |||
[[Category: Liederer BM]] | |||
[[Category: Liu Y]] | |||
[[Category: O'Brien T]] | |||
[[Category: Oeh J]] | |||
[[Category: Sampath D]] | |||
[[Category: Shen Y]] | |||
[[Category: Skelton N]] | |||
[[Category: Wang C]] | |||
[[Category: Wang L]] | |||
[[Category: Wang W]] | |||
[[Category: Wu H]] | |||
[[Category: Xiao Y]] | |||
[[Category: Yuen P]] | |||
[[Category: Zak M]] | |||
[[Category: Zhao G]] | |||
[[Category: Zhao Q]] | |||
[[Category: Zheng X]] | |||
Latest revision as of 15:24, 1 March 2024
Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
Structural highlights
FunctionNAMPT_HUMAN Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). See Also |
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