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{{STRUCTURE_4lg5|  PDB=4lg5  |  SCENE=  }}
===ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1===
{{ABSTRACT_PUBMED_23835477}}


==Function==
==ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1==
[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref> [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref> 
<StructureSection load='4lg5' size='340' side='right'caption='[[4lg5]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lg5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LG5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.88&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1O:QUINABACTIN'>A1O</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg5 OCA], [https://pdbe.org/4lg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lg5 RCSB], [https://www.ebi.ac.uk/pdbsum/4lg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lg5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>  


==About this Structure==
==See Also==
[[4lg5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG5 OCA].
*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
 
*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:023835477</ref><references group="xtra"/><references/>
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Large Structures]]
[[Category: Deng, P.]]
[[Category: Deng P]]
[[Category: Gao, M.]]
[[Category: Gao M]]
[[Category: Gao, P.]]
[[Category: Gao P]]
[[Category: Liu, X.]]
[[Category: Liu X]]
[[Category: Melcher, K.]]
[[Category: Melcher K]]
[[Category: Wang, F.]]
[[Category: Wang F]]
[[Category: Xu, H E.]]
[[Category: Xu HE]]
[[Category: Xu, Y.]]
[[Category: Xu Y]]
[[Category: Xue, X.]]
[[Category: Xue X]]
[[Category: Zeng, L.]]
[[Category: Zeng L]]
[[Category: Zhang, Y.]]
[[Category: Zhang Y]]
[[Category: Zhao, Y.]]
[[Category: Zhao Y]]
[[Category: Zhong, D.]]
[[Category: Zhong D]]
[[Category: Zhou, X E.]]
[[Category: Zhou XE]]
[[Category: Zhu, J K.]]
[[Category: Zhu J-K]]
[[Category: Abscisic acid mimicking compound]]
[[Category: Hydrolase-receptor-inhibitor complex]]
[[Category: Pp2c]]
[[Category: Pyr/pyl/rcar]]

Latest revision as of 15:19, 1 March 2024

ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1

Structural highlights

4lg5 is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.88Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PYL2_ARATH Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.[1] [2]

See Also

References

  1. ↑ Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009 Dec 3;462(7273):602-8. PMID:19898420 doi:10.1038/nature08613
  2. ↑ Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009 Dec;16(12):1230-6. Epub 2009 Nov 5. PMID:19893533 doi:10.1038/nsmb.1730

4lg5, resolution 2.88Å

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