2jf4: Difference between revisions

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-[[Image:2jf4.jpg|left|200px]]<br /><applet load="2jf4" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2jf4, resolution 2.20&Aring;" />
-'''FAMILY 37 TREHALASE FROM ESCHERICHIA COLI IN COMPLEX WITH VALIDOXYLAMINE'''<br />
-==About this Structure==
+==Family 37 trehalase from Escherichia coli in complex with validoxylamine==
-JF4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=VDM:'>VDM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Alpha,alpha-trehalase Alpha,alpha-trehalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.28 3.2.1.28] Known structural/functional Site: <scene name='pdbsite=ACD:Vdm+Binding+Site+For+Chain+A'>ACD</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JF4 OCA].
+<StructureSection load='2jf4' size='340' side='right'caption='[[2jf4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2jf4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JF4 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VDM:(1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL'>VDM</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alpha,alpha-trehalase Alpha,alpha-trehalase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.28 3.2.1.28] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jf4 OCA], [https://pdbe.org/2jf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jf4 RCSB], [https://www.ebi.ac.uk/pdbsum/2jf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jf4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[https://www.uniprot.org/uniprot/TREA_ECOLI TREA_ECOLI]] Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.[HAMAP-Rule:MF_01060]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/2jf4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jf4 ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Alpha,alpha-trehalase]]
-[[Category: Escherichia coli]]
+[[Category: Ecoli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Chiara, J L.]]
+[[Category: Chiara, J L]]
-[[Category: Davies, G J.]]
+[[Category: Davies, G J]]
-[[Category: Garcia, A.]]
+[[Category: Garcia, A]]
-[[Category: Gibson, R P.]]
+[[Category: Gibson, R P]]
-[[Category: Gloster, T M.]]
+[[Category: Gloster, T M]]
-[[Category: Gracia, I Storch De.]]
+[[Category: Gracia, I Storch De]]
-[[Category: Roberts, S.]]
+[[Category: Roberts, S]]
-[[Category: Warren, R A.J.]]
+[[Category: Warren, R A.J]]
-[[Category: VDM]]
+[[Category: Family 37]]
-[[Category: family 37]]
+[[Category: Glycosidase]]
-[[Category: glycosidase]]
+[[Category: Glycoside hydrolase]]
-[[Category: glycoside hydrolase]]
+[[Category: Hydrolase]]
-[[Category: hydrolase]]
+[[Category: Inhibitor]]
-[[Category: inhibitor]]
+[[Category: Periplasmic]]
-[[Category: periplasmic]]
+[[Category: Trehalase]]
-[[Category: trehalase]]
+[[Category: Validoxylamine]]
-[[Category: validoxylamine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:02:35 2008''