4lvd: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 4lvd is ON HOLD
+==Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)==
+<StructureSection load='4lvd' size='340' side='right'caption='[[4lvd]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4lvd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVD FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EB:N-(4-NITROPHENYL)CYCLOPROPANECARBOXAMIDE'>1EB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvd OCA], [https://pdbe.org/4lvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lvd RCSB], [https://www.ebi.ac.uk/pdbsum/4lvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
-Authors: Giannetti, AM, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y., Hua, R, Wang, C, Zhao, Q, Liederer, BM, Liu, Y, O Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P., Zak, M, Zhao, G, Dragovich, PS
+==See Also==
+*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
-Description: Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Bravo B]]
+[[Category: Dragovich PS]]
+[[Category: Feng Y]]
+[[Category: Giannetti AM]]
+[[Category: Gunzner-Toste J]]
+[[Category: Ho Y]]
+[[Category: Hua R]]
+[[Category: Liederer BM]]
+[[Category: Liu Y]]
+[[Category: O'Brien T]]
+[[Category: Oeh J]]
+[[Category: Sampath D]]
+[[Category: Shen Y]]
+[[Category: Skelton N]]
+[[Category: Wang C]]
+[[Category: Wang L]]
+[[Category: Wang W]]
+[[Category: Wu H]]
+[[Category: Xiao Y]]
+[[Category: Yuen P]]
+[[Category: Zak M]]
+[[Category: Zhao G]]
+[[Category: Zhao Q]]
+[[Category: Zheng X]]