4lhq: Difference between revisions
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The entry | ==Ricin A chain bound to camelid nanobody (VHH8)== | ||
<StructureSection load='4lhq' size='340' side='right'caption='[[4lhq]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4lhq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LHQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lhq OCA], [https://pdbe.org/4lhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lhq RCSB], [https://www.ebi.ac.uk/pdbsum/4lhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lhq ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). | |||
==See Also== | |||
*[[Ricin 3D structures|Ricin 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Ricinus communis]] | |||
[[Category: Vicugna pacos]] | |||
[[Category: Burshteyn F]] | |||
[[Category: Cassidy M]] | |||
[[Category: Cheung J]] | |||
[[Category: Franklin M]] | |||
[[Category: Gary E]] | |||
[[Category: Mantis N]] | |||
[[Category: Rudolph MJ]] | |||
Latest revision as of 15:19, 1 March 2024
Ricin A chain bound to camelid nanobody (VHH8)Ricin A chain bound to camelid nanobody (VHH8)
Structural highlights
FunctionRICI_RICCO Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). See Also |
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