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[[Image:2jax.jpg|left|200px]]<br /><applet load="2jax" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2jax, resolution 3.22&Aring;" />
'''UNIVERSAL STRESS PROTEIN RV2623 FROM MYCOBATERIUM TUBERCULOSIS'''<br />


==About this Structure==
==Universal Stress Protein Rv2623 from Mycobaterium Tuberculosis==
2JAX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=ATP:'>ATP</scene> and <scene name='pdbligand=UNX:'>UNX</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Atp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Atp+Binding+Site+For+Chain+A'>AC2</scene> and <scene name='pdbsite=AC3:Unk+Binding+Site+For+Chain+A'>AC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAX OCA].  
<StructureSection load='2jax' size='340' side='right'caption='[[2jax]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
[[Category: Mycobacterium tuberculosis]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2jax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAX FirstGlance]. <br>
[[Category: Bartunik, H D.]]
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
[[Category: Bourenkov, G.]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
[[Category: Oberschall, A.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jax OCA], [https://pdbe.org/2jax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jax RCSB], [https://www.ebi.ac.uk/pdbsum/2jax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jax ProSAT]</span></td></tr>
[[Category: Strizhov, N.]]
</table>
[[Category: ATP]]
== Function ==
[[Category: UNX]]
[[https://www.uniprot.org/uniprot/Y2623_MYCTU Y2623_MYCTU]] May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function.
[[Category: atp binding]]
== Evolutionary Conservation ==
[[Category: protein binding]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: universal stress protein]]
Check<jmol>
[[Category: usp]]
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jax_consurf.spt"</scriptWhenChecked>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:01:13 2008''
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jax ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Bartunik, H D]]
[[Category: Bourenkov, G]]
[[Category: Oberschall, A]]
[[Category: Strizhov, N]]
[[Category: Atp binding]]
[[Category: Protein binding]]
[[Category: Universal stress protein]]
[[Category: Usp]]

Latest revision as of 11:05, 19 January 2022

Universal Stress Protein Rv2623 from Mycobaterium TuberculosisUniversal Stress Protein Rv2623 from Mycobaterium Tuberculosis

Structural highlights

2jax is a 1 chain structure with sequence from Myctu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[Y2623_MYCTU] May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2jax, resolution 3.22Å

Drag the structure with the mouse to rotate

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