Arginine repressor: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='1xxb' size='350' side='right' caption='E. coli structure of arginine repressor C terminal hexamer complex with arginine (PDB entry [[1xxb]])' scene='55/554907/Cv/1'>
-<StructureSection load='3laj' size='350' side='right' caption='Structure of arginine repressor complex with DNA and arginine (PDB entry [[3laj]])' scene=''>
+== Function ==
-'''Arginine repressor''' (ArgR) is a prokaryotic repressor which regulates the arginine deiminase pathway.  In this pathway, arginine is metabolized to form ammonia, CO2 and ATP.  The ArgR releases the expression of the arginine deiminase pathway in the presence of arginine.  The genes controlled by ArgR are not found in a single operon.  While repressors are usually active as dimers, ArgR is a hexamer and binds to 2 palindromic DNA sites. The structure of ArgR shows a DNA-binding domain at the N-terminal and a C-terminal domain which contains the intersubunit interaction sites and the Arg binding site.
+'''Arginine repressor''' (ArgR) is a prokaryotic repressor which regulates the arginine deiminase pathway.  In this pathway, arginine is metabolized to form ammonia, CO2 and ATP.  The ArgR releases the expression of the arginine deiminase pathway in the presence of arginine.  The genes controlled by ArgR are not found in a single operon.  While repressors are usually active as dimers, ArgR is a hexamer and binds to 2 palindromic DNA sites called ARG box in its N terminal domain.<ref>PMID:10331868</ref>
-==3D structures of arginine repressor==
+== Structural highlights ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+The structure of ArgR shows a DNA-binding domain at the acidic N-terminal and a basic C-terminal domain which contains the <scene name='55/554907/Cv/5'>intersubunit interaction sites</scene> and the <scene name='55/554907/Cv/10'>Arg binding site</scene>. Every Arg ligand interacts <scene name='55/554907/Cv/11'>with residues from 3 subunits</scene>.<ref>PMID:8594204</ref>
-'''Arginine repressor'''
+==3D structures of arginine repressor==
+[[Arginine repressor 3D structures]]
-[[1b4a]] – GsArgR – ''Geobacillus stearothermophilus'' <br />
-[[1f9n]] – BsArgR – ''Bacillus subtilis'' <br />
-[[3v4g]] – ArgR – ''Vibrio vulnificus'' <br />
-[[3ere]] – MtArgR + DNA – ''Mycobacterium tuberculosis'' <br />
-[[3fhz]], [[3laj]] – MtArgR + DNA + Arg <br />
-[[3lap]] – MtArgR + DNA + canavanine <br />
-'''Arginine repressor N terminal'''
-[[1aoy]] – EcArgR N terminal - ''Escherichia coli'' - NMR<br />
-[[1b4b]] – BsArgR N terminal  <br />
-[[2p5l]] – BsArgR N terminal + DNA <br />
-'''Arginine repressor C terminal'''
+</StructureSection>
-[[1xxc]] – EcArgR C terminal <br />
+== References ==
-[[2p5k]] – GsArgR C terminal  <br />
+<references/>
-[[3bue]] – MtArgR C terminal  <br />
+[[Category:Topic Page]]
-[[1xxb]] – EcArgR C terminal + Arg <br />
-[[1xxa]], [[1xxb]] – EcArgR C terminal + Arg <br />
-[[2p5m]] – BsArgR C terminal (mutant) + Arg <br />
-[[2zfz]], [[3cag]] – MtArgR C terminal + Arg <br />