NF-kB: Difference between revisions
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<StructureSection load='1nfk' size='350' side='right' caption='Structure of mouse NF-kB1 p50 complex with DNA (PDB entry [[1nfk]])' scene=''> | <StructureSection load='1nfk' size='350' side='right' caption='Structure of mouse NF-kB1 p50 complex with DNA (PDB entry [[1nfk]])' scene=''> | ||
== Function == | |||
'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. There are 5 proteins in the NF-kB family: '''NF-kB1''' (synthesized as '''p105''' and processed to '''p50''') | '''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA<ref>PMID:15371334</ref>. I-κ-B-α is an inhibitor of NF-kB.<br /> | ||
There are 5 proteins in the NF-kB family:<br /> | |||
*'''NF-kB1''' (synthesized as '''p105''' and processed to '''p50''')<br /> | |||
*'''NF-kB2''' (synthesized as '''p100''' and processed to '''p52''')<br /> | |||
*'''RelA''' (or '''p65''' subunit of NF-kB)<br /> | |||
*'''RelB'''<br /> | |||
*'''cRel'''. | |||
See also [[NF-kB (hebrew)]]. | |||
== Relevance == | |||
NF-kB plays a critical role in cancer development and progression and may determine its response to therapy. NF-kB is a target for chemotherapeutic agents<ref>PMID:16673382</ref>. NF-kB is a critical link between inflammation and cancer<ref>PMID:20066113</ref>. | |||
</StructureSection> | |||
==3D structures of NF-kappaB== | ==3D structures of NF-kappaB== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*RelA (p65) | |||
**[[1bft]], [[1my5]] – mRelA dimerization domain – mouse <br /> | |||
**[[1my7]] – mRelA dimerization domain (mutant) <br /> | |||
**[[1ram]], [[2ram]] – mRelA residues 19-291 + DNA <br /> | |||
**[[1k3z]], [[1oy3]] – mRelA dimerization domain + I-κ-B-α <br /> | |||
*NF-kB1 (p50) | |||
[[ | **[[1svc]] – hp50 + DNA - human - NMR<br /> | ||
[[ | **[[1nfk]] – mp50 + DNA<br /> | ||
[[ | **[[1bfs]] – mp50 dimerization domain<br /> | ||
[[ | **[[1u36]], [[1u3j]], [[1u3y]], [[1u3z]], [[1u41]], [[1u42]] – mp50 dimerization domain (mutant)<br /> | ||
*NF-kB1 (p52) | |||
[[ | **[[7cli]], [[7vup]], [[7vuq]], [[7w7l]] – hp52 + DNA <br /> | ||
*NF-kB1 (p105) | |||
[[2dbf]] – hp105 death domain<br /> | **[[2dbf]] – hp105 death domain<br /> | ||
[[1ooa]] – mp105 + RNA<br /> | **[[1ooa]] – mp105 + RNA<br /> | ||
*NF-kB1 + RelA | |||
[[1nfi]] – hp50 + RelA + I-κ-B-α <br /> | **[[1nfi]] – hp50 + RelA + I-κ-B-α <br /> | ||
[[1ikn]] – mp50 + RelA + I-κ-B-α <br /> | **[[1ikn]] – mp50 + RelA + I-κ-B-α <br /> | ||
[[1vkx]], [[1le5]], [[1le9]], [[1lei]] – mp50 + RelA + DNA<br /> | **[[1vkx]], [[1le5]], [[1le9]], [[1lei]] – mp50 + RelA + DNA<br /> | ||
[[2i9t]] – mp105 + RelA + DNA<br /> | **[[2i9t]] – mp105 + RelA + DNA<br /> | ||
[[2v2t]] – mp50 + RelB + DNA<br /> | **[[2v2t]] – mp50 + RelB + DNA<br /> | ||
[[2o61]] – hp105 RHR domain + RelA + DNA<br /> | **[[2o61]] – hp105 RHR domain + RelA + DNA<br /> | ||
[[3gut]] – hp105 + RelA + DNA<br /> | **[[3gut]] – hp105 + RelA + DNA<br /> | ||
[[3jv4]] – hp105 dimerization domain + RelB dimerization domain<br /> | **[[3jv4]] – hp105 dimerization domain + RelB dimerization domain<br /> | ||
}} | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||