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{{STRUCTURE_4lct|  PDB=4lct  |  SCENE=  }}
===Crystal Structure and Versatile Functional Roles of the COP9 Signalosome Subunit 1===
{{ABSTRACT_PUBMED_23818606}}


==Function==
==Crystal Structure and Versatile Functional Roles of the COP9 Signalosome Subunit 1==
[[http://www.uniprot.org/uniprot/CSN1_ARATH CSN1_ARATH]] Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. In the complex, it plays a central role in CSN assembly.<ref>PMID:8689678</ref> <ref>PMID:11337587</ref>
<StructureSection load='4lct' size='340' side='right'caption='[[4lct]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lct]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LCT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lct OCA], [https://pdbe.org/4lct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lct RCSB], [https://www.ebi.ac.uk/pdbsum/4lct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lct ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CSN1_ARATH CSN1_ARATH] Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. In the complex, it plays a central role in CSN assembly.<ref>PMID:8689678</ref> <ref>PMID:11337587</ref>  


==About this Structure==
==See Also==
[[4lct]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LCT OCA].
*[[Signalosome|Signalosome]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:023818606</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Borgmann, M.]]
[[Category: Large Structures]]
[[Category: Lee, J H.]]
[[Category: Borgmann M]]
[[Category: Li, J.]]
[[Category: Lee J-H]]
[[Category: Naumann, M.]]
[[Category: Li J]]
[[Category: Schweitzer, K.]]
[[Category: Naumann M]]
[[Category: Wu, H.]]
[[Category: Schweitzer K]]
[[Category: Yi, L.]]
[[Category: Wu H]]
[[Category: Signaling protein]]
[[Category: Yi L]]

Latest revision as of 15:18, 1 March 2024

Crystal Structure and Versatile Functional Roles of the COP9 Signalosome Subunit 1Crystal Structure and Versatile Functional Roles of the COP9 Signalosome Subunit 1

Structural highlights

4lct is a 4 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CSN1_ARATH Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. In the complex, it plays a central role in CSN assembly.[1] [2]

See Also

References

  1. ↑ Chamovitz DA, Wei N, Osterlund MT, von Arnim AG, Staub JM, Matsui M, Deng XW. The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. Cell. 1996 Jul 12;86(1):115-21. PMID:8689678
  2. ↑ Schwechheimer C, Serino G, Callis J, Crosby WL, Lyapina S, Deshaies RJ, Gray WM, Estelle M, Deng XW. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science. 2001 May 18;292(5520):1379-82. Epub 2001 May 3. PMID:11337587 doi:10.1126/science.1059776

4lct, resolution 2.70Å

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