Opioid receptor: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Karsten Theis

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+<StructureSection load='' size='350' side='right' caption='Structure of κ-opioid receptor complex with opioid antagonist, citric acid, PEG and octadec-enoate derivative (PDB entry [[4djh]])' scene='55/553941/Cv/1' pspeed='8'>
+== Function ==
+'''Opioid receptor''' (OpR) is a [[G protein-coupled receptor]] with [[opioids]] as ligands<ref>PMID:22204322</ref>.  OpR types are classified according to the ligands which bind to them.<br />
+*  The '''μ-opioid receptor''' binds morphine.  For more details on μ-opioid receptor see<br />
+**[[Mu Opioid Receptor Bound to a Morphinan Antagonist]]
+**[[Kratom]]
+**[[μ Opioid Receptors]]
+**[[Mu Opioid Receptor]]
+**[[Antagonists]]
+**[[6dde]] μ-opioid receptor: G protein complex<br />
+*  The '''κ-opioid receptor''' binds opium-type ligands.  For details see [[Student Project 3 for UMass Chemistry 423 Spring 2015]].<br />
+*  The '''δ-opioid receptor''' binds enkephalins.  For details see [[Delta opioid receptor]].
+*  The '''Nociceptin/orphanin FQ opioid receptor''' binds the heptadecapeptide orphanin<ref>PMID:23395957</ref>.
-<StructureSection load='4djh' size='350' side='right' caption='Structure of κ-opioid receptor complex with opioid antagonist (PDB entry [[4djh]])' scene=''>
+See also
+*[[Opioids]]
-'''Opioid receptor''' (OpR) is a G protein-coupled receptor with opioids as ligands.  OpR types are classified according to the ligands which bind to them.  The '''μ-opioid receptor''' binds morphine; The '''κ-opioid receptor''' binds opium-type ligands; The '''δ-opioid receptor''' binds enkephalins.  For more details on μ-opioid receptor see [[Mu Opioid Receptor Bound to a Morphinan Antagonist]].
+*[[Opioid receptors]]
+*[[Treatments:Opioid drugs]]
+*[[Tutorial: The opioid receptor, a molecular switch]]
+*[[Transmembrane (cell surface) receptors]]
+== Relevance ==
+Nociceptin/orphanin FQ opioid receptor plays a role in the regulation of reward and motivation of substance abuse and is a target of drug abuse medication<ref>PMID:21050175</ref>.  Its agonists are useful in treatment of pain, anxiety, edema and more and its antagonists are useful in pain management, depression, dementia and Parkinson disease<ref>PMID:17266536</ref>.
+== Structural highlights ==
+The <scene name='55/553941/Cv/6'>κ-opioid receptor</scene> has a <scene name='55/553941/Cv/7'>large binding pocket</scene><ref>PMID:22437504</ref>. <scene name='55/553941/Cv/8'>Active site</scene>. Water molecules are shown as red spheres.
+</StructureSection>
 ==3D structures of opioid receptor==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
+*δ-opioid receptor
+**[[4ej4]] – mOpR + naltrindole - mouse <br />
+**[[6pt2]] – hOpR + peptide antagonist - human <br />
+**[[6pt3]] – hOpR + antagonist <br />
+**[[8f7s]] – hOpR + GI + deltorphin – Cryo EM <br />
+*κ-opioid receptor
-'''δ-opioid receptor'''
+**[[4djh]] – hOpR + opioid antagonist<br />
+**[[6vi4]] – hOpR (mutant) + nanobody<br />
+**[[7yit]] – hOpR (mutant) + nanobody + cytochrome b562<br />
+**[[7y1f]] – hOpR + GI + nanobody + dynorphin peptide – Cryo EM  <br />
+**[[8dzr]] – hOpR (mutant`) + GI + nanobody + gustucin peptide – Cryo EM  <br />
+**[[8dzp]], [[8dzs]] – hOpR (mutant`) + GI + nanobody + ligand – Cryo EM  <br />
-[[4ej4]] – mOpR + naltrindole - mouse <br />
+*Nociceptin/orphanin FQ opioid receptor
-'''κ-opioid receptor'''
+**[[4ea3]] – hOpR + peptide mimetic <br />
+**[[8f7w]], [[8f7x]] – hOpR + GI + nanobody + nociceptin peptide – Cryo EM  <br />
-[[4djh]] – hOpR + opioid antagonist - human <br />
+*μ-opioid receptor
-'''Nociceptin/orphanin FQ opioid receptor'''
+**[[8efq]] – hOpR + GI + DAMGO peptide – Cryo EM  <br />
+**[[8f7r]] – hOpR + GI + nanobody + endomorphin peptide – Cryo EM  <br />
+**[[8f7q]] – hOpR + GI + nanobody + endorphin peptide – Cryo EM  <br />
+**[[8ef6]] – hOpR + GI + nanobody + morphin – Cryo EM  <br />
+**[[7t2h]], [[7u2k]], [[8ef5]], [[8efb]], [[8efl]], [[8efo]] – hOpR + GI + nanobody + drug – Cryo EM  <br />
+**[[4dkl]], [[5c1m]] – mOpR + opioid antagonist  <br />
+**[[6ddf]] – mOpR + GI + DAMGO peptide – Cryo EM  <br />
+**[[7u2l]] – mOpR + GI + nanobody – Cryo EM  <br />
+**[[6dde]] – mOpR + GI + nanobody + DAMGO peptide – Cryo EM  <br />
+**[[7t2g]] – mOpR + GI + antagonist – Cryo EM  <br />
+**[[7scg]] – mOpR + GI + nanobody + antagonist – Cryo EM  <br />
+**[[7ul4]] – mOpR + megabody + drug – Cryo EM  <br />
-[[4ea3]] – hOpR + peptide mimetic <br />
+}}
-'''μ-opioid receptor'''
-[[4dkl]] – mOpR + opioid antagonist  <br />
+== References ==
+<references/>
+[[Category:Topic Page]]