G09SecL04Tpc2: Difference between revisions
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<Structure load='1FJ1' size='400' frame='true' align='right' caption='OspA Dimer (magenta and cyan) with LA-2 Antibody DImer; light chain(grey and pink), heavy chain (green and yellow) '/> | <Structure load='1FJ1' size='400' frame='true' align='right' caption='OspA Dimer (magenta and cyan) with LA-2 Antibody DImer; light chain(grey and pink), heavy chain (green and yellow) (PDB code [[1fj1]]) '/> | ||
'''Outer Surface Protein A (OspA)''' is a major lipoprotein on the ''borrelia burgdorferi'' [http://en.wikipedia.org/wiki/Spirochete spirochete], which is a causative agent of [http://en.wikipedia.org/wiki/Lyme_Disease Lyme Disease]. The three loops in the C-terminus define the [http://en.wikipedia.org/wiki/Protein_dimer dimerized] antigen-antibody complex. Shown to the right is the <scene name='G09SecL04Tpc2/Osp_a_dimer_with_la-2_antibody/1'> OspA dimer with LA-2 Antibody complex</scene>. The interaction between the loops and the LA-2 antibody forms the basis for successful OspA vaccination of this infectious disease. Most early symptoms include fever and headaches that are often eliminated through antibiotics. On the other hand, OspA has many important functions that are associated with late stage neurological disorders of the central nervous system including acute Lyme [http://en.wikipedia.org/wiki/Neuroborreliosis Neuroborreliosis], which can be extremely difficult to treat and disabling of the physical body itself.<ref name=art9>PMID 16040645</ref> | '''Outer Surface Protein A (OspA)''' is a major lipoprotein on the ''borrelia burgdorferi'' [http://en.wikipedia.org/wiki/Spirochete spirochete], which is a causative agent of [http://en.wikipedia.org/wiki/Lyme_Disease Lyme Disease]. The three loops in the C-terminus define the [http://en.wikipedia.org/wiki/Protein_dimer dimerized] antigen-antibody complex. Shown to the right is the <scene name='G09SecL04Tpc2/Osp_a_dimer_with_la-2_antibody/1'> OspA dimer with LA-2 Antibody complex</scene>. The interaction between the loops and the LA-2 antibody forms the basis for successful OspA vaccination of this infectious disease. Most early symptoms include fever and headaches that are often eliminated through antibiotics. On the other hand, OspA has many important functions that are associated with late stage neurological disorders of the central nervous system including acute Lyme [http://en.wikipedia.org/wiki/Neuroborreliosis Neuroborreliosis], which can be extremely difficult to treat and disabling of the physical body itself.<ref name=art9>PMID 16040645</ref> | ||
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== Outer Surface Protein A (OspA) == | == Outer Surface Protein A (OspA) == | ||
=== Structural Breakdown === | === Structural Breakdown === | ||
<Structure load='1fj1' size='300' frame='true' align='left' caption='Outer Surface Protein A' scene='G09SecL04Tpc2/Newfirst/1' /> | <Structure load='1fj1' size='300' frame='true' align='left' caption='Outer Surface Protein A [[1fj1]]' scene='G09SecL04Tpc2/Newfirst/1' /> | ||
<scene name='G09SecL04Tpc2/Newfirst/1'>Reset Model</scene> | <scene name='G09SecL04Tpc2/Newfirst/1'>Reset Model</scene> | ||
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=== LA-2 Recognition === | === LA-2 Recognition === | ||
<Structure load='1fj1' size='300' frame='true' align='right' caption='OspA and LA-2 Fab Complex ' scene='G09SecL04Tpc2/Ospala2/1' /> | <Structure load='1fj1' size='300' frame='true' align='right' caption='OspA and LA-2 Fab Complex [[1fj1]] ' scene='G09SecL04Tpc2/Ospala2/1' /> | ||
<scene name='G09SecL04Tpc2/Ospala2/1'>Reset Model</scene> | <scene name='G09SecL04Tpc2/Ospala2/1'>Reset Model</scene> | ||