2hw5: Difference between revisions

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-[[Image:2hw5.gif|left|200px]]<br /><applet load="2hw5" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2hw5, resolution 2.55&Aring;" />
-'''The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1'''<br />
-==About this Structure==
+==The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1==
-HW5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=COO:'>COO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Enoyl-CoA_hydratase Enoyl-CoA hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW5 OCA].
+<StructureSection load='2hw5' size='340' side='right'caption='[[2hw5]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
-[[Category: Enoyl-CoA hydratase]]
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2hw5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HW5 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COO:CROTONYL+COENZYME+A'>COO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hw5 OCA], [https://pdbe.org/2hw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hw5 RCSB], [https://www.ebi.ac.uk/pdbsum/2hw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hw5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ECHM_HUMAN ECHM_HUMAN] Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/2hw5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hw5 ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Enoyl-CoA hydratase 3D structures|Enoyl-CoA hydratase 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith C]]
-[[Category: Debreczeni, J.]]
+[[Category: Debreczeni J]]
-[[Category: Delft, F von.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Gileadi O]]
-[[Category: Gileadi, O.]]
+[[Category: Gorrec F]]
-[[Category: Gorrec, F.]]
+[[Category: Kavanagh K]]
-[[Category: Kavanagh, K.]]
+[[Category: Niesen F]]
-[[Category: Niesen, F.]]
+[[Category: Oppermann U]]
-[[Category: Oppermann, U.]]
+[[Category: Pike ACW]]
-[[Category: Pike, A C.W.]]
+[[Category: Salah E]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Sundstrom M]]
-[[Category: Salah, E.]]
+[[Category: Turnbull AP]]
-[[Category: Sundstrom, M.]]
+[[Category: Ugochukwu E]]
-[[Category: Turnbull, A P.]]
+[[Category: Umeano C]]
-[[Category: Ugochukwu, E.]]
+[[Category: Weigelt J]]
-[[Category: Umeano, C.]]
+[[Category: Von Delft F]]
-[[Category: Weigelt, J.]]
-[[Category: COO]]
-[[Category: MG]]
-[[Category: beta-oxidation]]
-[[Category: coa]]
-[[Category: enoyl-coa hydratase]]
-[[Category: fatty acid metabolism]]
-[[Category: hydratase/isomerase superfamily]]
-[[Category: lyase]]
-[[Category: sgc]]
-[[Category: structural genomics]]
-[[Category: structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:46:22 2008''