3td3: Difference between revisions

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{{STRUCTURE_3td3|  PDB=3td3  |  SCENE=  }}
===Crystal structure of OmpA-like domain from Acinetobacter baumannii in complex with glycine===
{{ABSTRACT_PUBMED_21965596}}


==Function==
==Crystal structure of OmpA-like domain from Acinetobacter baumannii in complex with glycine==
[[http://www.uniprot.org/uniprot/OMP38_ACIBA OMP38_ACIBA]] Porin. Induces apoptosis in human laryngeal epithelial HEp-2 cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor).<ref>PMID:16008580</ref> <ref>PMID:9928952</ref>
<StructureSection load='3td3' size='340' side='right'caption='[[3td3]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3td3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TD3 FirstGlance]. <br>
[[3td3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TD3 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3td3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3td3 OCA], [https://pdbe.org/3td3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3td3 RCSB], [https://www.ebi.ac.uk/pdbsum/3td3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3td3 ProSAT]</span></td></tr>
<ref group="xtra">PMID:021965596</ref><references group="xtra"/><references/>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OMP38_ACIB2 OMP38_ACIB2] Functions as a porin (PubMed:9928952). Induces apoptosis in human cell lines through caspase-dependent and AIF-dependent pathways. Purified Omp38 enters host cell and localizes to the mitochondria, which presumably leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor) (PubMed:16008580). Binds peptidoglycan, contributes to cell wall maintenance (Probable).<ref>PMID:16008580</ref> <ref>PMID:9928952</ref> <ref>PMID:16008580</ref> <ref>PMID:21965596</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Acinetobacter baumannii]]
[[Category: Acinetobacter baumannii]]
[[Category: Kim, H Y.]]
[[Category: Large Structures]]
[[Category: Lee, W C.]]
[[Category: Kim HY]]
[[Category: Park, J S.]]
[[Category: Lee WC]]
[[Category: Song, J H.]]
[[Category: Park JS]]
[[Category: Cell-wall attachment]]
[[Category: Song JH]]
[[Category: Membrane protein]]
[[Category: Ompa-like fold]]
[[Category: Peptide binding protein]]
[[Category: Peptidoglycan-binding]]

Latest revision as of 11:37, 20 March 2024

Crystal structure of OmpA-like domain from Acinetobacter baumannii in complex with glycineCrystal structure of OmpA-like domain from Acinetobacter baumannii in complex with glycine

Structural highlights

3td3 is a 8 chain structure with sequence from Acinetobacter baumannii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.59Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OMP38_ACIB2 Functions as a porin (PubMed:9928952). Induces apoptosis in human cell lines through caspase-dependent and AIF-dependent pathways. Purified Omp38 enters host cell and localizes to the mitochondria, which presumably leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor) (PubMed:16008580). Binds peptidoglycan, contributes to cell wall maintenance (Probable).[1] [2] [3] [4]

References

  1. ↑ Choi CH, Lee EY, Lee YC, Park TI, Kim HJ, Hyun SH, Kim SA, Lee SK, Lee JC. Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells. Cell Microbiol. 2005 Aug;7(8):1127-38. PMID:16008580 doi:CMI538
  2. ↑ Jyothisri K, Deepak V, Rajeswari MR. Purification and characterization of a major 40 kDa outer membrane protein of Acinetobacter baumannii. FEBS Lett. 1999 Jan 22;443(1):57-60. PMID:9928952
  3. ↑ Choi CH, Lee EY, Lee YC, Park TI, Kim HJ, Hyun SH, Kim SA, Lee SK, Lee JC. Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells. Cell Microbiol. 2005 Aug;7(8):1127-38. PMID:16008580 doi:CMI538
  4. ↑ Park JS, Lee WC, Yeo KJ, Ryu KS, Kumarasiri M, Hesek D, Lee M, Mobashery S, Song JH, Kim SI, Lee JC, Cheong C, Jeon YH, Kim HY. Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane. FASEB J. 2011 Sep 30. PMID:21965596 doi:10.1096/fj.11-188425

3td3, resolution 1.59Å

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