2m8k: Difference between revisions

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-{{STRUCTURE_2m8k|  PDB=2m8k  |  SCENE=  }}
-===A pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo===
-==About this Structure==
+==A pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo==
-[[2m8k]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8K OCA].
+<StructureSection load='2m8k' size='340' side='right'caption='[[2m8k]]' scene=''>
-[[Category: Brown, Y.]]
+== Structural highlights ==
-[[Category: Cash, D D.]]
+<table><tr><td colspan='2'>[[2m8k]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M8K FirstGlance]. <br>
-[[Category: Cohen, O.]]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-[[Category: Feigon, J.]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m8k OCA], [https://pdbe.org/2m8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m8k RCSB], [https://www.ebi.ac.uk/pdbsum/2m8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m8k ProSAT]</span></td></tr>
-[[Category: Kim, N.]]
+</table>
-[[Category: Shefer, K.]]
+<div style="background-color:#fffaf0;">
-[[Category: Tzfati, Y.]]
+== Publication Abstract from PubMed ==
-[[Category: Ulyanov, N B.]]
+Telomerase is a ribonucleoprotein complex that extends the 3' ends of linear chromosomes. The specialized telomerase reverse transcriptase requires a multidomain RNA (telomerase RNA, TER), which includes an integral RNA template and functionally important template-adjacent pseudoknot. The structure of the human TER pseudoknot revealed that the loops interact with the stems to form a triple helix shown to be important for activity in vitro. A similar triple helix has been predicted to form in diverse fungi TER pseudoknots. The solution NMR structure of the Kluyveromyces lactis pseudoknot, presented here, reveals that it contains a long pyrimidine motif triple helix with unexpected features that include three individual bulge nucleotides and a C+*G-C triple adjacent to a stem 2-loop 2 junction. Despite significant differences in sequence and base triples, the 3D shape of the human and K. lactis TER pseudoknots are remarkably similar. Analysis of the effects of nucleotide substitutions on cell growth and telomere lengths provides evidence that this conserved structure forms in endogenously assembled telomerase and is essential for telomerase function in vivo.
-[[Category: Pseudoknot]]
-[[Category: Rna]]
+Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo.,Cash DD, Cohen-Zontag O, Kim NK, Shefer K, Brown Y, Ulyanov NB, Tzfati Y, Feigon J Proc Natl Acad Sci U S A. 2013 Jun 17. PMID:23776224<ref>PMID:23776224</ref>
-[[Category: Rna triplex]]
-[[Category: Telomerase]]
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2m8k" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Telomerase 3D structures|Telomerase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Brown Y]]
+[[Category: Cash DD]]
+[[Category: Cohen O]]
+[[Category: Feigon J]]
+[[Category: Kim N]]
+[[Category: Shefer K]]
+[[Category: Tzfati Y]]
+[[Category: Ulyanov NB]]