3t6b: Difference between revisions

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-{{STRUCTURE_3t6b|  PDB=3t6b  |  SCENE=  }}
-===Structure of human DPPIII in complex with the opioid peptide Tynorphin, at 2.4 Angstroms===
-{{ABSTRACT_PUBMED_22493238}}
-==Function==
+==Structure of human DPPIII in complex with the opioid peptide Tynorphin, at 2.4 Angstroms==
-[[http://www.uniprot.org/uniprot/DPP3_HUMAN DPP3_HUMAN]] Cleaves Arg-Arg-beta-naphthylamide.
+<StructureSection load='3t6b' size='340' side='right'caption='[[3t6b]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3t6b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T6B FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t6b OCA], [https://pdbe.org/3t6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t6b RCSB], [https://www.ebi.ac.uk/pdbsum/3t6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t6b ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DPP3_HUMAN DPP3_HUMAN] Cleaves Arg-Arg-beta-naphthylamide.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Opioid peptides are involved in various essential physiological processes, most notably nociception. Dipeptidyl peptidase III (DPP III) is one of the most important enkephalin-degrading enzymes associated with the mammalian pain modulatory system. Here we describe the X-ray structures of human DPP III and its complex with the opioid peptide tynorphin, which rationalize the enzyme's substrate specificity and reveal an exceptionally large domain motion upon ligand binding. Microcalorimetric analyses point at an entropy-dominated process, with the release of water molecules from the binding cleft ("entropy reservoir") as the major thermodynamic driving force. Our results provide the basis for the design of specific inhibitors that enable the elucidation of the exact role of DPP III and the exploration of its potential as a target of pain intervention strategies.
-==About this Structure==
+Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III.,Bezerra GA, Dobrovetsky E, Viertlmayr R, Dong A, Binter A, Abramic M, Macheroux P, Dhe-Paganon S, Gruber K Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6525-30. Epub 2012 Apr 9. PMID:22493238<ref>PMID:22493238</ref>
-[[3t6b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6B OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:022493238</ref><references group="xtra"/><references/>
+</div>
-[[Category: Dipeptidyl-peptidase III]]
+<div class="pdbe-citations 3t6b" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Dipeptidyl peptidase 3D structures|Dipeptidyl peptidase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Bezerra, G A.]]
+[[Category: Large Structures]]
-[[Category: Gruber, K.]]
+[[Category: Bezerra GA]]
-[[Category: Domain motion]]
+[[Category: Gruber K]]
-[[Category: Entropy binding]]
-[[Category: Human dipeptidylpeptidase iii]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]
-[[Category: Opioid peptide complex]]