4f3c: Difference between revisions

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{{STRUCTURE_4f3c|  PDB=4f3c  |  SCENE=  }}
===Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with butyl-thio-DADMe-Immucillin-A===
{{ABSTRACT_PUBMED_23685211}}


==Function==
==Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with butyl-thio-DADMe-Immucillin-A==
[[http://www.uniprot.org/uniprot/E8NLP5_SALET E8NLP5_SALET]] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity).[HAMAP-Rule:MF_01684]  
<StructureSection load='4f3c' size='340' side='right'caption='[[4f3c]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4f3c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Choleraesuis_str._SCSA50 Salmonella enterica subsp. enterica serovar Choleraesuis str. SCSA50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F3C FirstGlance]. <br>
[[4f3c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_choleraesuis_str._scsa50 Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3C OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BIG:(3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(BUTYLSULFANYL)METHYL]PYRROLIDIN-3-OL'>BIG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f3c OCA], [https://pdbe.org/4f3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f3c RCSB], [https://www.ebi.ac.uk/pdbsum/4f3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f3c ProSAT]</span></td></tr>
<ref group="xtra">PMID:023685211</ref><references group="xtra"/><references/>
</table>
[[Category: Adenosylhomocysteine nucleosidase]]
__TOC__
[[Category: Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50]]
</StructureSection>
[[Category: Almo, S C.]]
[[Category: Large Structures]]
[[Category: Bonanno, J B.]]
[[Category: Salmonella enterica subsp. enterica serovar Choleraesuis str. SCSA50]]
[[Category: Haapalainen, A M.]]
[[Category: Almo SC]]
[[Category: Schramm, V L.]]
[[Category: Bonanno JB]]
[[Category: Thomas, K.]]
[[Category: Haapalainen AM]]
[[Category: 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase]]
[[Category: Schramm VL]]
[[Category: Acting on glycosyl bond]]
[[Category: Thomas K]]
[[Category: Adenosylhomocysteine nucleosidase activity]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: L-methionine biosynthetic process from s-adenosylmethionine]]
[[Category: L-methionine salvage from methylthioadenosine]]
[[Category: Methylthioadenosine nucleosidase activity]]

Latest revision as of 14:09, 1 March 2024

Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with butyl-thio-DADMe-Immucillin-ACrystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with butyl-thio-DADMe-Immucillin-A

Structural highlights

4f3c is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar Choleraesuis str. SCSA50. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.93Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

4f3c, resolution 1.93Å

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OCA
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