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{{STRUCTURE_3roh|  PDB=3roh  |  SCENE=  }}
===Crystal Structure of Leukotoxin (LukE) from Staphylococcus aureus subsp. aureus COL.===


==About this Structure==
==Crystal Structure of Leukotoxin (LukE) from Staphylococcus aureus subsp. aureus COL.==
[[3roh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_tch70 Staphylococcus aureus subsp. aureus tch70]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROH OCA].  
<StructureSection load='3roh' size='340' side='right'caption='[[3roh]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
[[Category: Staphylococcus aureus subsp. aureus tch70]]
== Structural highlights ==
[[Category: Anderson, W F.]]
<table><tr><td colspan='2'>[[3roh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ROH FirstGlance]. <br>
[[Category: Bagnoli, F.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
[[Category: Bottomley, M.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3roh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3roh OCA], [https://pdbe.org/3roh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3roh RCSB], [https://www.ebi.ac.uk/pdbsum/3roh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3roh ProSAT]</span></td></tr>
[[Category: Dubrovska, I.]]
</table>
[[Category: Falugi, F.]]
== Function ==
[[Category: Grandi, G.]]
[https://www.uniprot.org/uniprot/LUKEV_STAA8 LUKEV_STAA8] Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells. The activity of LukEv-LukDv to rabbit leukocytes is similar to that of the Panton-Valentine leucocidin (PVL). LukEv-LukDv is hemolytic to rabbit red blood cells although the activity is only 8% of gamma-hemolysin.<ref>PMID:12636257</ref>
[[Category: Halavaty, A.]]
== References ==
[[Category: Minasov, G.]]
<references/>
[[Category: Shuvalova, L.]]
__TOC__
[[Category: Winsor, J.]]
</StructureSection>
[[Category: Center for structural genomics of infectious disease]]
[[Category: Large Structures]]
[[Category: Csgid]]
[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
[[Category: Leukocidin]]
[[Category: Anderson WF]]
[[Category: Leukocidin-like]]
[[Category: Bagnoli F]]
[[Category: Membrane and cell surface proteins and peptide]]
[[Category: Bottomley M]]
[[Category: Pore-forming toxin]]
[[Category: Dubrovska I]]
[[Category: Structural genomic]]
[[Category: Falugi F]]
[[Category: Toxin]]
[[Category: Grandi G]]
[[Category: Halavaty A]]
[[Category: Minasov G]]
[[Category: Shuvalova L]]
[[Category: Winsor J]]

Latest revision as of 15:31, 14 March 2024

Crystal Structure of Leukotoxin (LukE) from Staphylococcus aureus subsp. aureus COL.Crystal Structure of Leukotoxin (LukE) from Staphylococcus aureus subsp. aureus COL.

Structural highlights

3roh is a 1 chain structure with sequence from Staphylococcus aureus subsp. aureus NCTC 8325. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LUKEV_STAA8 Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells. The activity of LukEv-LukDv to rabbit leukocytes is similar to that of the Panton-Valentine leucocidin (PVL). LukEv-LukDv is hemolytic to rabbit red blood cells although the activity is only 8% of gamma-hemolysin.[1]

References

  1. ↑ Morinaga N, Kaihou Y, Noda M. Purification, cloning and characterization of variant LukE-LukD with strong leukocidal activity of staphylococcal bi-component leukotoxin family. Microbiol Immunol. 2003;47(1):81-90. PMID:12636257

3roh, resolution 3.20Å

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