4kk2: Difference between revisions

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-'''Unreleased structure'''
-The entry 4kk2 is ON HOLD
+==Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure==
+<StructureSection load='4kk2' size='340' side='right'caption='[[4kk2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors: Vetting, M.W., Toro, R., Bhosle, R., Al Obaidi, N.F., Washington, E., Scott Glenn, A., Chowdhury, S., Evans, B., Hammonds, J., Hillerich, B., Love, J., Seidel, R.D., Imker, H.J., Poulter, C.D., Gerlt, J.A., Almo, S.C., Enzyme Function Initiative
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4kk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Artemisia_spiciformis Artemisia spiciformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KK2 FirstGlance]. <br>
-Description: Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kk2 OCA], [https://pdbe.org/4kk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4kk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kk2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FPPS1_ARTSI FPPS1_ARTSI] Catalyzes the sequential condensation of isopentenyl pyrophosphate (IPP) with the allylic pyrophosphates, dimethylallyl pyrophosphate (DMAPP), and then with the resultant geranylpyrophosphate (GPP) to the ultimate product farnesyl pyrophosphate (FPP). Has a 4.5 time greater affinity for GPP versus DMAPP.<ref>PMID:12782626</ref> [https://www.uniprot.org/uniprot/CHRDS_ARTSI CHRDS_ARTSI] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.<ref>PMID:12782626</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Artemisia spiciformis]]
+[[Category: Large Structures]]
+[[Category: Al Obaidi NF]]
+[[Category: Almo SC]]
+[[Category: Bhosle R]]
+[[Category: Chowdhury S]]
+[[Category: Evans B]]
+[[Category: Gerlt JA]]
+[[Category: Hammonds J]]
+[[Category: Hillerich B]]
+[[Category: Imker HJ]]
+[[Category: Love J]]
+[[Category: Poulter CD]]
+[[Category: Scott Glenn A]]
+[[Category: Seidel RD]]
+[[Category: Toro R]]
+[[Category: Vetting MW]]
+[[Category: Washington E]]