2g89: Difference between revisions

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[[Image:2g89.gif|left|200px]]<br /><applet load="2g89" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2g89, resolution 2.50&Aring;" />
'''L. casei thymidylate synthase Y261A in complex with substrate, dUMP'''<br />


==About this Structure==
==L. casei thymidylate synthase Y261A in complex with substrate, dUMP==
2G89 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei] with <scene name='pdbligand=UMP:'>UMP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G89 OCA].
<StructureSection load='2g89' size='340' side='right'caption='[[2g89]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
[[Category: Lactobacillus casei]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2g89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G89 FirstGlance]. <br>
[[Category: Thymidylate synthase]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
[[Category: Finer-Moore, J S.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
[[Category: Stroud, R M.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g89 OCA], [https://pdbe.org/2g89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g89 RCSB], [https://www.ebi.ac.uk/pdbsum/2g89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g89 ProSAT]</span></td></tr>
[[Category: UMP]]
</table>
[[Category: active site mutation]]
== Function ==
[[Category: alpha/beta protein]]
[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
[[Category: beta sheet]]
== Evolutionary Conservation ==
[[Category: dump complex]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: dump-binding residue]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g89_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g89 ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:29:08 2008''
==See Also==
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Lacticaseibacillus casei]]
[[Category: Large Structures]]
[[Category: Finer-Moore JS]]
[[Category: Stroud RM]]

Latest revision as of 12:26, 14 February 2024

L. casei thymidylate synthase Y261A in complex with substrate, dUMPL. casei thymidylate synthase Y261A in complex with substrate, dUMP

Structural highlights

2g89 is a 1 chain structure with sequence from Lacticaseibacillus casei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TYSY_LACCA Provides the sole de novo source of dTMP for DNA biosynthesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2g89, resolution 2.50Å

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