4bl5: Difference between revisions
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==Crystal structure of human GDP-L-fucose synthase with bound NADP and product GDP-L-fucose== | |||
<StructureSection load='4bl5' size='340' side='right'caption='[[4bl5]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4bl5]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BL5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GFB:GUANOSINE-5-DIPHOSPHATE-BETA-L-FUCOPYRANOSE'>GFB</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bl5 OCA], [https://pdbe.org/4bl5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bl5 RCSB], [https://www.ebi.ac.uk/pdbsum/4bl5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bl5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FCL_HUMAN FCL_HUMAN] Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Bradley A]] | |||
[[Category: Edwards A]] | |||
[[Category: Kavanagh K]] | |||
[[Category: Krojer T]] | |||
[[Category: Oppermann U]] | |||
[[Category: Raynor JW]] | |||
[[Category: Rojkova A]] | |||
[[Category: Shafqat N]] | |||
[[Category: Vollmar M]] | |||
[[Category: Yue WW]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 14:53, 20 December 2023
Crystal structure of human GDP-L-fucose synthase with bound NADP and product GDP-L-fucoseCrystal structure of human GDP-L-fucose synthase with bound NADP and product GDP-L-fucose
Structural highlights
FunctionFCL_HUMAN Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. |
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