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{{STRUCTURE_3ovb|  PDB=3ovb  |  SCENE=  }}
===How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA===
{{ABSTRACT_PUBMED_21071662}}


==Function==
==How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA==
[[http://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU]] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref>
<StructureSection load='3ovb' size='340' side='right'caption='[[3ovb]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ovb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OVB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ovb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ovb OCA], [https://pdbe.org/3ovb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ovb RCSB], [https://www.ebi.ac.uk/pdbsum/3ovb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ovb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref>  


==About this Structure==
==See Also==
[[3ovb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVB OCA].
*[[CCA-adding enzyme 3D structures|CCA-adding enzyme 3D structures]]
 
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
==Reference==
== References ==
<ref group="xtra">PMID:021071662</ref><references group="xtra"/><references/>
<references/>
__TOC__
</StructureSection>
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
[[Category: Pan, B C.]]
[[Category: Large Structures]]
[[Category: Steitz, T A.]]
[[Category: Pan BC]]
[[Category: Xiong, Y.]]
[[Category: Steitz TA]]
[[Category: Cca-adding]]
[[Category: Xiong Y]]
[[Category: Nucleotidyltransfer]]
[[Category: Protein-rna]]
[[Category: Rossmann fold]]
[[Category: Transferase-rna complex]]
[[Category: Trna]]

Latest revision as of 13:36, 21 February 2024

How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNAHow the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA

Structural highlights

3ovb is a 4 chain structure with sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CCA_ARCFU Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.[1]

See Also

References

  1. ↑ Okabe M, Tomita K, Ishitani R, Ishii R, Takeuchi N, Arisaka F, Nureki O, Yokoyama S. Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure. EMBO J. 2003 Nov 3;22(21):5918-27. PMID:14592988 doi:http://dx.doi.org/10.1093/emboj/cdg563

3ovb, resolution 1.95Å

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