User:Fadel A. Samatey/FlhBc I: Difference between revisions
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<span style="font-size:160%"><b>Inhibition of a type III secretion system by the deletion of a short loop in one of its membrane proteins.</b></span><br><br> | <span style="font-size:160%"><b>Inhibition of a type III secretion system by the deletion of a short loop in one of its membrane proteins.</b></span><br><br> | ||
<span style="font-size:120%">Vladimir A. Meshcheryakov, Akio Kitao, Hideyuki Matsunami and [[Fadel A. Samatey Group|Fadel A. Samatey]] ([[Fadel A. Samatey Group (Japanese)|サマテ]]). ''Acta Cryst. D69: 812-820 (2013). [http://dx.doi.org/10.1107/S0907444913002102 doi:10.1107/S0907444913002102] <span style="background-color:#ffff80;padding:3px;"><i>Open Access.</i></span></span> | <span style="font-size:120%">Vladimir A. Meshcheryakov, Akio Kitao, Hideyuki Matsunami and [[Fadel A. Samatey Group|Fadel A. Samatey]] ([[Fadel A. Samatey Group (Japanese)|サマテ]]). ''Acta Cryst. D69: 812-820 (2013). [http://dx.doi.org/10.1107/S0907444913002102 doi:10.1107/S0907444913002102] <span style="background-color:#ffff80;padding:3px;"><i>Open Access.</i></span></span> | ||
<br> | |||
Contact: [[Image:Samatey-email-address.png|160px]] | |||
===Brief Introduction=== | ===Brief Introduction=== | ||
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==Molecular Tour: FlhBc Structures== | ==Molecular Tour: FlhBc Structures== | ||
<StructureSection size=' | <!--<StructureSection size='400' frame='true' align='right' caption='Cytoplasmic domain of FlhB' scene='User:Fadel_A._Samatey/Workbench/I3DC-1/Flhb_st/6' >--> | ||
<StructureSection load='' size='400' side='right' caption='Cytoplasmic domain of FlhB' scene='User:Fadel_A._Samatey/Workbench/I3DC-1/Flhb_st/6'> | |||
<!--<table cellpadding="6" style="background-color:#ffff80"><tr><td> | <!--<table cellpadding="6" style="background-color:#ffff80"><tr><td> | ||
This page is under construction. We expect to complete additional interactive molecular scenes before May 5, 2013. | This page is under construction. We expect to complete additional interactive molecular scenes before May 5, 2013. | ||
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<jmol> | <jmol> | ||
<jmolButton> | <jmolButton> | ||
<script>if ({1.2}.count > 0); compare {1.1} {1.2} SUBSET {*.ca} {246-269:A} {240-263:C} {272-280:B} {266-274:D} {285-351:B} {279-345:D} ATOMS rotate translate; zoomto *1.5;spin y; else; set echo bottom left; color echo white; font echo 20 sansserif;echo "Please display both structures first!"; delay 4; set echo off; endif;</script> | <script>if ({1.2}.count > 0); compare {1.1} {1.2} SUBSET {*.ca} {246-269:A} {240-263:C} {272-280:B} {266-274:D} {285-351:B} {279-345:D} ATOMS rotate translate 3; zoomto *1.5;spin y; else; set echo bottom left; color echo white; font echo 20 sansserif;echo "Please display both structures first!"; delay 4; set echo off; endif;</script> | ||
<text>Do Structural Alignment</text> | <text>Do Structural Alignment</text> | ||
</jmolButton> | </jmolButton> | ||
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There is a prominent strip of conserved residues on one side of the long N-terminal alpha helix. As mentioned above, the auto-catalytically cleaved segment, including 269 and 270, is highly conserved. In contrast (as mentioned above) the protruding loop 281-285 (which is necessary for function and suggested to be important for flexibility of the N terminus) is not conserved. | There is a prominent strip of conserved residues on one side of the long N-terminal alpha helix. As mentioned above, the auto-catalytically cleaved segment, including 269 and 270, is highly conserved. In contrast (as mentioned above) the protruding loop 281-285 (which is necessary for function and suggested to be important for flexibility of the N terminus) is not conserved. | ||
Conservation of ''A. aeolicus'' FlhBc was similar, especially in the regions mentioned above. | Conservation of ''A. aeolicus'' FlhBc (not shown) was similar, especially in the regions mentioned above. | ||
Turning to the positive charges discussed above, <scene name='User:Fadel_A._Samatey/FlhBc_I/Conservation_st/3'>here only positively charged sidechains (Lys, Arg) are spacefilling. His is depicted in sticks.</scene> All atoms are colored by conservation. With spinning off, touch any sidechain to report its identity. | Turning to the positive charges discussed above, <scene name='User:Fadel_A._Samatey/FlhBc_I/Conservation_st/3'>here only positively charged sidechains (Lys, Arg) are spacefilling. His is depicted in sticks.</scene> All atoms are colored by conservation. With spinning off, touch any sidechain to report its identity. | ||
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</StructureSection> | </StructureSection> | ||
===References and Notes=== | ===References and Notes=== | ||
* If you have any comments, questions, or if there is any problem with this page, please contact [[Image:Samatey-email-address.png|150px]]. | |||
<references /> | <references /> | ||
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