3n4j: Difference between revisions

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{{STRUCTURE_3n4j|  PDB=3n4j  |  SCENE=  }}
===Putative RNA methyltransferase from Yersinia pestis===


==Function==
==Putative RNA methyltransferase from Yersinia pestis==
[[http://www.uniprot.org/uniprot/Q74Y93_YERPE Q74Y93_YERPE]] Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity).  
<StructureSection load='3n4j' size='340' side='right'caption='[[3n4j]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3n4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N4J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n4j OCA], [https://pdbe.org/3n4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n4j RCSB], [https://www.ebi.ac.uk/pdbsum/3n4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n4j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRML_YERPE TRML_YERPE] Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.[HAMAP-Rule:MF_01885]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/3n4j_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n4j ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
[[3n4j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N4J OCA].
*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
[[Category: Yersinia pestis]]
__TOC__
[[Category: Anderson, W F.]]
</StructureSection>
[[Category: Joachimiak, A.]]
[[Category: Large Structures]]
[[Category: Maltseva, N.]]
[[Category: Yersinia pestis CO92]]
[[Category: Osipiuk, J.]]
[[Category: Anderson WF]]
[[Category: Peterson, S.]]
[[Category: Joachimiak A]]
[[Category: Center for structural genomics of infectious disease]]
[[Category: Maltseva N]]
[[Category: Csgid]]
[[Category: Osipiuk J]]
[[Category: Rna methyltransferase]]
[[Category: Peterson S]]
[[Category: Transferase]]

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