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{{STRUCTURE_3n8h|  PDB=3n8h  |  SCENE=  }}
===Crystal Structure of Pantoate-beta-alanine Ligase from Francisella tularensis===


==Function==
==Crystal Structure of Pantoate-beta-alanine Ligase from Francisella tularensis==
[[http://www.uniprot.org/uniprot/PANC_FRATT PANC_FRATT]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity).  
<StructureSection load='3n8h' size='340' side='right'caption='[[3n8h]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3n8h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis_SCHU_S4 Francisella tularensis subsp. tularensis SCHU S4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N8H FirstGlance]. <br>
[[3n8h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis Francisella tularensis subsp. tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N8H OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.001&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n8h OCA], [https://pdbe.org/3n8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n8h RCSB], [https://www.ebi.ac.uk/pdbsum/3n8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n8h ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/3n8h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n8h ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Pantothenate synthetase|Pantothenate synthetase]]
*[[Pantothenate synthetase|Pantothenate synthetase]]
[[Category: Francisella tularensis subsp. tularensis]]
__TOC__
[[Category: Pantoate--beta-alanine ligase]]
</StructureSection>
[[Category: Anderson, W F.]]
[[Category: Francisella tularensis subsp. tularensis SCHU S4]]
[[Category: Joachimiak, A.]]
[[Category: Large Structures]]
[[Category: Kim, Y.]]
[[Category: Anderson WF]]
[[Category: Maltseva, N.]]
[[Category: Joachimiak A]]
[[Category: Papazisi, L.]]
[[Category: Kim Y]]
[[Category: Alpha-beta sandwich]]
[[Category: Maltseva N]]
[[Category: Center for structural genomics of infectious disease]]
[[Category: Papazisi L]]
[[Category: Csgid]]
[[Category: Ligase]]
[[Category: Structural genomic]]
[[Category: Structural genomics of infectious disease]]

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