3mpx: Difference between revisions

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-{{STRUCTURE_3mpx|  PDB=3mpx  |  SCENE=  }}
-===Crystal structure of the DH and PH-1 domains of human FGD5===
-==Function==
+==Crystal structure of the DH and PH-1 domains of human FGD5==
-[[http://www.uniprot.org/uniprot/FGD5_HUMAN FGD5_HUMAN]] Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
+<StructureSection load='3mpx' size='340' side='right'caption='[[3mpx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[3mpx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MPX FirstGlance]. <br>
-[[3mpx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPX OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mpx OCA], [https://pdbe.org/3mpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mpx RCSB], [https://www.ebi.ac.uk/pdbsum/3mpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mpx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FGD5_HUMAN FGD5_HUMAN] Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/3mpx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mpx ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Bochkarev, A.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C.]]
+[[Category: Bochkarev A]]
-[[Category: Crombet, L.]]
+[[Category: Bountra C]]
-[[Category: Edwards, A M.]]
+[[Category: Crombet L]]
-[[Category: Nedyalkova, L.]]
+[[Category: Edwards AM]]
-[[Category: Park, H.]]
+[[Category: Nedyalkova L]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Park H]]
-[[Category: Shen, Y.]]
+[[Category: Shen Y]]
-[[Category: Tempel, W.]]
+[[Category: Tempel W]]
-[[Category: Tong, Y.]]
+[[Category: Tong Y]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Dh domain]]
-[[Category: Lipid binding protein]]
-[[Category: Ph domain]]
-[[Category: Sgc]]
-[[Category: Structural genomics consortium]]