4jzy: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
New page: '''Unreleased structure''' The entry 4jzy is ON HOLD Authors: Anna Czarna, Alex Berndt, Hari Raj Singh, Astrid Grudziecki, Andreas Ladurner, Gyula Timinszky, Achim Kramer, Eva Wolf Des...
 
No edit summary
 
(7 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 4jzy is ON HOLD
==Crystal structures of Drosophila Cryptochrome==
<StructureSection load='4jzy' size='340' side='right'caption='[[4jzy]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jzy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JZY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jzy OCA], [https://pdbe.org/4jzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jzy RCSB], [https://www.ebi.ac.uk/pdbsum/4jzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jzy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CRY1_DROME CRY1_DROME] Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing.<ref>PMID:9845369</ref> <ref>PMID:10063806</ref> <ref>PMID:9845370</ref> <ref>PMID:10233998</ref> <ref>PMID:10417378</ref> <ref>PMID:16527739</ref> <ref>PMID:17298948</ref> <ref>PMID:18641630</ref> <ref>PMID:18597555</ref>


Authors: Anna Czarna, Alex Berndt, Hari Raj Singh, Astrid Grudziecki, Andreas Ladurner, Gyula Timinszky, Achim Kramer, Eva Wolf
==See Also==
 
*[[Cryptochrome 3D structures|Cryptochrome 3D structures]]
Description: Crystal structures of Drosophila Cryptochrome
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Czarna A]]
[[Category: Wolf E]]

Latest revision as of 15:07, 1 March 2024

Crystal structures of Drosophila CryptochromeCrystal structures of Drosophila Cryptochrome

Structural highlights

4jzy is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.34Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CRY1_DROME Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing.[1] [2] [3] [4] [5] [6] [7] [8] [9]

See Also

References

  1. ↑ Emery P, So WV, Kaneko M, Hall JC, Rosbash M. CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell. 1998 Nov 25;95(5):669-79. PMID:9845369
  2. ↑ Okano S, Kanno S, Takao M, Eker AP, Isono K, Tsukahara Y, Yasui A. A putative blue-light receptor from Drosophila melanogaster. Photochem Photobiol. 1999 Jan;69(1):108-13. PMID:10063806
  3. ↑ Stanewsky R, Kaneko M, Emery P, Beretta B, Wager-Smith K, Kay SA, Rosbash M, Hall JC. The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell. 1998 Nov 25;95(5):681-92. PMID:9845370
  4. ↑ Egan ES, Franklin TM, Hilderbrand-Chae MJ, McNeil GP, Roberts MA, Schroeder AJ, Zhang X, Jackson FR. An extraretinally expressed insect cryptochrome with similarity to the blue light photoreceptors of mammals and plants. J Neurosci. 1999 May 15;19(10):3665-73. PMID:10233998
  5. ↑ Ceriani MF, Darlington TK, Staknis D, Mas P, Petti AA, Weitz CJ, Kay SA. Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science. 1999 Jul 23;285(5427):553-6. PMID:10417378
  6. ↑ Collins B, Mazzoni EO, Stanewsky R, Blau J. Drosophila CRYPTOCHROME is a circadian transcriptional repressor. Curr Biol. 2006 Mar 7;16(5):441-9. PMID:16527739 doi:S0960-9822(06)01043-8
  7. ↑ Berndt A, Kottke T, Breitkreuz H, Dvorsky R, Hennig S, Alexander M, Wolf E. A novel photoreaction mechanism for the circadian blue light photoreceptor Drosophila cryptochrome. J Biol Chem. 2007 Apr 27;282(17):13011-21. Epub 2007 Feb 12. PMID:17298948 doi:M608872200
  8. ↑ Gegear RJ, Casselman A, Waddell S, Reppert SM. Cryptochrome mediates light-dependent magnetosensitivity in Drosophila. Nature. 2008 Aug 21;454(7207):1014-8. doi: 10.1038/nature07183. Epub 2008 Jul 20. PMID:18641630 doi:10.1038/nature07183
  9. ↑ Hoang N, Schleicher E, Kacprzak S, Bouly JP, Picot M, Wu W, Berndt A, Wolf E, Bittl R, Ahmad M. Human and Drosophila cryptochromes are light activated by flavin photoreduction in living cells. PLoS Biol. 2008 Jul 1;6(7):e160. doi: 10.1371/journal.pbio.0060160. PMID:18597555 doi:10.1371/journal.pbio.0060160

4jzy, resolution 2.34Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4jzy&oldid=4074644"