CREB-binding protein: Difference between revisions

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<StructureSection load='3p1c' size='350' side='right' scene='54/541099/Cv/1' caption='Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]]'> 
[[Image:1kbh.png|left|200px|thumb|Crystal structure of  CREB-binding protein complex with nuclear receptor coactivator [[1kbh]]]]
== Function ==
{{STRUCTURE_1kbh|  PDB=1kbh  | SIZE=350| SCENE= |right|CAPTION=CREB-binding protein complex with nuclear receptor coactivator [[1kbh]] }}


'''CREB-binding protein''' or '''CREBBP''' (CBP) is a transcription activator.  CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription.  CBP acetylates histones.  It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref>


== Disease ==


Mutations in CBP cause Rubinstein-Taybi syndrome.<ref>PMID:7630403</ref>


== Structural highlights ==


CBP contains several domains.  Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53;  IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.


<scene name='54/541099/Cv/5'>Acetyllysine binding site</scene> with chain A. Water molecules are shown as red spheres.


 
<scene name='54/541099/Cv/6'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref>
 
 
 
 
 
 
 
 
 
 
 
 
'''CREB-binding protein''' (CBP) is a transcription activator.  CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription.  CBP acetylates histones.  It binds to phosphorylated CREB and enhances its activity.  CBP contains several domains.  Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53;  IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 interacts with the N-terminal of p73.


== 3D Structures of CREB-binding protein ==
== 3D Structures of CREB-binding protein ==
[[CREB-binding protein 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
 
[[1kdx]] – mCBP KIX domain – mouse <br />
[[4i9o]] – mCBP GACKIX domain (mutant)  <br />
[[1f81]] – mCBP TAZ2 domain  <br />
[[1u2n]] – mCBP TAZ1 domain - NMR <br />
[[1jjs]] – mCBP IBiD domain - NMR<br />
[[1liq]] – mCBP CH1 domain - NMR<br />
[[1tot]] – mCBP ZZ domain – NMR <br />
[[2kkj]] – mCBP nuclear coactivator binding domain - NMR <br />
[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />
[[2d82]] – hCBP bromodomain  - NMR<br />
[[3dwy]] – hCBP bromodomain  <br />
[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]] – hCBP bromodomain  + small molecule<br />
[[2l84]], [[2l85]] – hCBP bromodomain  + small molecule - NMR<br />
 
===CBP complex with protein===


[[1kbh]] – hCBP + nuclear receptor coactivator  <br />
== References ==
[[2zoq]] – hCBP + interferon regulatory factor 3  <br />
<references/>
[[2c52]] – mCBP residues 2059-2117 + nuclear receptor coactivator  - NMR<br />
[[Category:Topic Page]]
[[1r8u]] – mCBP TAZ1 domain + P300-interacting transactivator - human <br />
[[1l8c]] – mCBP TAZ1 domain  + hypoxia-inducible factor 1α<br />
[[2ka6]] – mCBP TAZ2 domain  + STAT1-TAD - NMR<br />
[[2ka4]] – mCBP TAZ2 domain  + STAT2-TAD - NMR<br />
[[2kje]] – hCBP TAZ2 domain  + adenoviral E1A peptide - NMR<br />
[[1jsp]] – hCBP bromodomain  + p53 peptide<br />
[[2l14]] – mCBP  nuclear coactivator binding domain + p53 peptide - NMR<br />
[[1sb0]] – mCBP KIX domain + protein c-Myb – NMR <br />
[[2agh]] – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR <br />
[[2lqh]], [[2lqi]] – mCBP KIX domain + forkhead box O3 – NMR <br />
[[2kwf]] – hCBP KIX domain + transcription factor 4 – NMR <br />
[[2rny]] – hCBP bromodomain  + histone H3 peptide - NMR<br />

Latest revision as of 12:28, 30 November 2022

Function

CREB-binding protein or CREBBP (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. [1]

Disease

Mutations in CBP cause Rubinstein-Taybi syndrome.[2]

Structural highlights

CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.

with chain A. Water molecules are shown as red spheres.

with chain B (3p1c).[3]

3D Structures of CREB-binding protein

CREB-binding protein 3D structures


Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions 3p1c

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993 Oct 28;365(6449):855-9. PMID:8413673 doi:http://dx.doi.org/10.1038/365855a0
  2. ↑ Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ, et al.. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature. 1995 Jul 27;376(6538):348-51. PMID:7630403 doi:http://dx.doi.org/10.1038/376348a0
  3. ↑ Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell. 2012 Mar 30;149(1):214-31. PMID:22464331 doi:10.1016/j.cell.2012.02.013

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