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[[Image:2egv.jpg|left|200px]]<br /><applet load="2egv" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2egv, resolution 1.45&Aring;" />
'''Crystal structure of rRNA methyltransferase with SAM ligand'''<br />


==About this Structure==
==Crystal structure of rRNA methyltransferase with SAM ligand==
2EGV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus] with <scene name='pdbligand=SAM:'>SAM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EGV OCA].  
<StructureSection load='2egv' size='340' side='right'caption='[[2egv]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2egv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EGV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2egv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2egv OCA], [https://pdbe.org/2egv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2egv RCSB], [https://www.ebi.ac.uk/pdbsum/2egv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2egv ProSAT], [https://www.topsan.org/Proteins/RSGI/2egv TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RSME_AQUAE RSME_AQUAE] Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eg/2egv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2egv ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bessho, Y.]]
[[Category: Bessho Y]]
[[Category: Dong, X.]]
[[Category: Dong X]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: SAM]]
[[Category: m3u]]
[[Category: methyltransferase]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: pua domain]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rna methyltransferase]]
[[Category: rrna modification]]
[[Category: rsgi]]
[[Category: rsme]]
[[Category: sam]]
[[Category: structural genomics]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:09:54 2008''

Latest revision as of 16:49, 13 March 2024

Crystal structure of rRNA methyltransferase with SAM ligandCrystal structure of rRNA methyltransferase with SAM ligand

Structural highlights

2egv is a 2 chain structure with sequence from Aquifex aeolicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.45Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

RSME_AQUAE Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2egv, resolution 1.45Å

Drag the structure with the mouse to rotate

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