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{{STRUCTURE_3mdb|  PDB=3mdb  |  SCENE=  }}
===Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4===


==Function==
==Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4==
[[http://www.uniprot.org/uniprot/KI13B_HUMAN KI13B_HUMAN]] Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.<ref>PMID:20194617</ref> [[http://www.uniprot.org/uniprot/ADAP1_HUMAN ADAP1_HUMAN]] GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).<ref>PMID:10448098</ref> <ref>PMID:10333475</ref>
<StructureSection load='3mdb' size='340' side='right'caption='[[3mdb]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3mdb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MDB FirstGlance]. <br>
[[3mdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDB OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.952&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IP9:(2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIOCTANOATE'>IP9</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdb OCA], [https://pdbe.org/3mdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mdb RCSB], [https://www.ebi.ac.uk/pdbsum/3mdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdb ProSAT]</span></td></tr>
<references group="xtra"/><references/>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KI13B_HUMAN KI13B_HUMAN] Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.<ref>PMID:20194617</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/3mdb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mdb ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bochkarev, A.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Bochkarev A]]
[[Category: Edwards, A M.]]
[[Category: Bountra C]]
[[Category: MacKenzie, F.]]
[[Category: Edwards AM]]
[[Category: Park, H.]]
[[Category: MacKenzie F]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Park H]]
[[Category: Shen, L.]]
[[Category: Shen L]]
[[Category: Tempel, W.]]
[[Category: Tempel W]]
[[Category: Tong, Y.]]
[[Category: Tong Y]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Atp-binding]]
[[Category: Cytoskeleton]]
[[Category: Gap]]
[[Category: Gtpase activation]]
[[Category: Kinesin]]
[[Category: Metal-binding]]
[[Category: Microtubule]]
[[Category: Motor protein]]
[[Category: Nucleotide-binding]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
[[Category: Transport protein-hydrolase activator complex]]
[[Category: Zinc-finger]]

Latest revision as of 11:51, 6 September 2023

Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4

Structural highlights

3mdb is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.952Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KI13B_HUMAN Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Yoshimura Y, Terabayashi T, Miki H. Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. Mol Cell Biol. 2010 May;30(9):2206-19. doi: 10.1128/MCB.01181-09. Epub 2010 Mar, 1. PMID:20194617 doi:10.1128/MCB.01181-09

3mdb, resolution 2.95Å

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