3lit: Difference between revisions

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-{{STRUCTURE_3lit|  PDB=3lit  |  SCENE=  }}
-===The crystal structure of htlv protease complexed with the inhibitor KNI-10681===
-{{ABSTRACT_PUBMED_20600105}}
-==About this Structure==
+==The crystal structure of htlv protease complexed with the inhibitor KNI-10681==
-[[3lit]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_1 Human t-lymphotropic virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIT OCA].
+<StructureSection load='3lit' size='340' side='right'caption='[[3lit]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3lit]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_T-cell_leukemia_virus_type_I Human T-cell leukemia virus type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LIT FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E15:(4R)-3-[(2S,3S)-3-[[(2S)-2-[[(2S)-2-AZANYL-2-PHENYL-ETHANOYL]AMINO]-3,3-DIMETHYL-BUTANOYL]AMINO]-2-HYDROXY-4-PHENYL-BUTANOYL]-5,5-DIMETHYL-N-[(2R)-3-METHYLBUTAN-2-YL]-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>E15</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lit OCA], [https://pdbe.org/3lit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lit RCSB], [https://www.ebi.ac.uk/pdbsum/3lit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lit ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q82134_9DELA Q82134_9DELA]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/li/3lit_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lit ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus associated with several serious diseases, such as adult T-cell leukemia and tropical spastic paraparesis/myelopathy. For a number of years, the protease (PR) encoded by HTLV-1 has been a target for designing antiviral drugs, but that effort was hampered by limited available structural information. We report a high-resolution crystal structure of HTLV-1 PR complexed with a statine-containing inhibitor, a significant improvement over the previously available moderate-resolution structure. We also report crystal structures of the complexes of HTLV-1 PR with five different inhibitors that are more compact and more potent. A detailed study of structure-activity relationships was performed to interpret in detail the influence of the polar and hydrophobic interactions between the inhibitors and the protease.
-==Reference==
+Crystal structures of inhibitor complexes of human T-cell leukemia virus (HTLV-1) protease.,Satoh T, Li M, Nguyen JT, Kiso Y, Gustchina A, Wlodawer A J Mol Biol. 2010 Aug 27;401(4):626-41. Epub 2010 Jun 30. PMID:20600105<ref>PMID:20600105</ref>
-<ref group="xtra">PMID:020600105</ref><references group="xtra"/><references/>
-[[Category: Human t-lymphotropic virus 1]]
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Gustchina, A.]]
+</div>
-[[Category: Kiso, Y.]]
+<div class="pdbe-citations 3lit" style="background-color:#fffaf0;"></div>
-[[Category: Li, M.]]
-[[Category: Nguyen, J.]]
+==See Also==
-[[Category: Satoh, T.]]
+*[[Virus protease 3D structures|Virus protease 3D structures]]
-[[Category: Wlodawer, A.]]
+== References ==
-[[Category: Hydrolase]]
+<references/>
-[[Category: Hydrolase-hydrolase inhibitor complex]]
+__TOC__
+</StructureSection>
+[[Category: Human T-cell leukemia virus type I]]
+[[Category: Large Structures]]
+[[Category: Gustchina A]]
+[[Category: Kiso Y]]
+[[Category: Li M]]
+[[Category: Nguyen J]]
+[[Category: Satoh T]]
+[[Category: Wlodawer A]]