2dsf: Difference between revisions

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-[[Image:2dsf.gif|left|200px]]<br /><applet load="2dsf" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2dsf, resolution 2.80&Aring;" />
-'''Structure of the complex of C-terminal lobe of bovine lactoferrin with xylose at 2.8A resolution'''<br />
-==About this Structure==
+==Structure of the complex of C-terminal lobe of bovine lactoferrin with xylose at 2.8A resolution==
-DSF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=LXC:'>LXC</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=FE:'>FE</scene>, <scene name='pdbligand=CO3:'>CO3</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSF OCA].
+<StructureSection load='2dsf' size='340' side='right'caption='[[2dsf]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2dsf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSF FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LXC:BETA-L-XYLOPYRANOSE'>LXC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsf OCA], [https://pdbe.org/2dsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsf RCSB], [https://www.ebi.ac.uk/pdbsum/2dsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>   Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>   Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>   The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dsf ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Lactoferrin|Lactoferrin]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Bos taurus]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Bhushan, A.]]
+[[Category: Bhushan A]]
-[[Category: Mir, R.]]
+[[Category: Mir R]]
-[[Category: Sharma, S.]]
+[[Category: Sharma S]]
-[[Category: Singh, N.]]
+[[Category: Singh N]]
-[[Category: Singh, T P.]]
+[[Category: Singh TP]]
-[[Category: Sinha, M.]]
+[[Category: Sinha M]]
-[[Category: CO3]]
-[[Category: FE]]
-[[Category: LXC]]
-[[Category: NAG]]
-[[Category: SO4]]
-[[Category: ZN]]
-[[Category: complex]]
-[[Category: sugar]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:02:06 2008''