4jck: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4jck is ON HOLD
+==Galectin-3 carbohydrate recognition domain in complex with thioditaloside==
+<StructureSection load='4jck' size='340' side='right'caption='[[4jck]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4jck]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JCK FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PRD_900109:thioditaloside'>PRD_900109</scene>, <scene name='pdbligand=SDY:beta-D-talopyranose'>SDY</scene>, <scene name='pdbligand=TWJ:1-thio-beta-D-talopyranose'>TWJ</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jck OCA], [https://pdbe.org/4jck PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jck RCSB], [https://www.ebi.ac.uk/pdbsum/4jck PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jck ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
-Authors: Bum-Erdene, K., Blanchard, H.
+==See Also==
+*[[Galectin 3D structures|Galectin 3D structures]]
-Description: Galectin-3 carbohydrate recognition domain in complex with thioditaloside
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Blanchard H]]
+[[Category: Bum-Erdene K]]