|
|
| (4 intermediate revisions by the same user not shown) |
| Line 1: |
Line 1: |
| {{STRUCTURE_3rut| PDB=3rut | SCENE= }}
| |
| ===FXR with SRC1 and GSK359===
| |
| {{ABSTRACT_PUBMED_21890356}}
| |
|
| |
|
| ==Disease== | | ==FXR with SRC1 and GSK359== |
| [[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children. | | <StructureSection load='3rut' size='340' side='right'caption='[[3rut]], [[Resolution|resolution]] 3.00Å' scene=''> |
| | == Structural highlights == |
| | <table><tr><td colspan='2'>[[3rut]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RUT FirstGlance]. <br> |
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=59G:6-(4-{[3-(2,6-DICHLOROPHENYL)-5-(PROPAN-2-YL)-1,2-OXAZOL-4-YL]METHOXY}PHENYL)-1-BENZOTHIOPHENE-3-CARBOXYLIC+ACID'>59G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rut OCA], [https://pdbe.org/3rut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rut RCSB], [https://www.ebi.ac.uk/pdbsum/3rut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rut ProSAT]</span></td></tr> |
| | </table> |
| | == Function == |
| | [https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> |
|
| |
|
| ==Function== | | ==See Also== |
| [[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref><ref>PMID:10334993</ref><ref>PMID:12815072</ref><ref>PMID:15471871</ref><ref>PMID:12718892</ref><ref>PMID:18621523</ref><ref>PMID:19410460</ref><ref>PMID:19586769</ref> [[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.<ref>PMID:9427757</ref><ref>PMID:7481822</ref><ref>PMID:9223431</ref><ref>PMID:9296499</ref><ref>PMID:9223281</ref><ref>PMID:10449719</ref><ref>PMID:12954634</ref> | | *[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]] |
| | | == References == |
| ==About this Structure==
| | <references/> |
| [[3rut]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RUT OCA].
| | __TOC__ |
| | | </StructureSection> |
| ==Reference== | |
| <ref group="xtra">PMID:021890356</ref><references group="xtra"/><references/>
| |
| [[Category: Histone acetyltransferase]]
| |
| [[Category: Homo sapiens]] | | [[Category: Homo sapiens]] |
| [[Category: Madauss, K P.]] | | [[Category: Large Structures]] |
| [[Category: Williams, S P.]] | | [[Category: Madauss KP]] |
| [[Category: Alpha-helical sandwich]] | | [[Category: Williams SP]] |
| [[Category: Bile acid]]
| |
| [[Category: Farnesoid]]
| |
| [[Category: Nuclear receptor]]
| |
| [[Category: Rxr]]
| |
| [[Category: Transcription co-factor]]
| |
| [[Category: Transcription factor]]
| |
| [[Category: Transcription regulator]]
| |